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Nucleosome positioning and transcription: fission yeast CHD remodellers make their move. | LitMetric

Nucleosome positioning and transcription: fission yeast CHD remodellers make their move.

EMBO J

INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.

Published: November 2012

AI Article Synopsis

Article Abstract

Regularly positioned nucleosomes are a common feature of 5' ends of most eukaryotic genes. A series of three studies, Shim et al (2012) and Pointner et al (2012) in this issue of The EMBO Journal and Hennig et al (2012) in EMBO Reports, now show that in the fission yeast Schizosaccharomyces pombe this intragenic nucleosome positioning mostly requires two ATP-dependent remodellers of the CHD family, Hrp1 and Hrp3. Moreover, they suggest that Hrp1- and Hrp3-dependent nucleosome spacing contributes to the silencing of cryptic antisense transcription.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512389PMC
http://dx.doi.org/10.1038/emboj.2012.284DOI Listing

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