Topical tacrolimus with custom trays in the treatment of severe oral chronic graft-versus-host disease refractory to a potent topical steroid therapy: a case report. | LitMetric
Background: The authors present a case demonstrating the success of topical tacrolimus (TAC) therapy with custom trays in the treatment of oral chronic graft-versus-host disease (cGVHD). The 41-year-old male patient initially responded to topical steroid therapy (clobetasol propionate 0.05% ointment) applied both topically and with flexible carrier trays, but later became refractory to this potent topical agent. Topical TAC therapy with flexible carrier trays and systemic prednisone therapy was initiated.
Results: The patient responded favorably with the change to topical TAC therapy with custom trays (and oral prednisone). His oral cGVHD lesions resolved within a period of 4 weeks. The improvement has remained stable at 14 months of follow-up.
Clinical Implications: This is the first case reported with regard to the successful resolution of steroid recalcitrant cGVHD successfully treated with topical TAC with custom trays.
is a diverse genus of evergreen and deciduous species grown in gardens worldwide for their attractive flowers and foliage. In summer 2023, nine of 12 potted 'Nova Zembla' plants purchased from a wholesale nursery in Ohio exhibited wilting, leaf and stem discoloration, and severely darkened and softened roots, which eventually progressed into dieback and plant death. Roots tested positive with a Phytophthora Immunostrip® (Agdia, Inc.
State Key Laboratory of Oral & Max Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address:
Objectives: To evaluate the accuracy of direct restorations using transparent vinyl polysiloxane (VPS) indices with different thicknesses for composite resin injection technique.
Methods: Thirty-six standard resin teeth of tooth #11 were divided into 3 groups based on the index thickness including 2, 4, and 6 mm (n = 12). VPS indices were fabricated using customized trays corresponding to each thickness.
Roth | McFarlane Hand and Upper Limb Centre, St Joseph's Health Care, London, Canada; Department of Surgery, Western University, London, Canada. Electronic address:
Background: Anterior shoulder pain after reverse shoulder arthroplasty (RSA) is not uncommon and may be due to humeral impingement against the conjoint tendon during internal rotation (IR). It is unknown what effect different implant designs and configurations have on conjoint tendon impingement. The purpose of this study was to investigate the influence of several RSA implant design parameters on conjoint tendon impingement during IR.
In November 2022, two 'Shenandoah' European pears at the USDA Appalachian Fruit Research Station exhibited significant decay, with over 75% of the surface showing brown discoloration and softening, which indicated a potential fungal disease.
Tissue samples from the affected pears were collected, purified, and the fungal isolate was found to have rapid growth characteristics and distinct conidia (spore) sizes.
Genetic analysis revealed that the isolate (WV22SR1P5) is closely related to a Diaporthe species known for affecting cucumbers, suggesting this may be a newly identified pathogen not yet formally classified.
Objectives: To investigate dimensional accuracy of polyether (PE) and vinylpolysiloxane (VPS) impressions taken with manually fabricated and 3D-printed trays.
Materials And Methods: To evaluate impression accuracy, highly precise digital data of a metallic lower jaw model with prepared teeth (regions 34 and 36), an implant (region 47) and three precision balls placed occlusally along the dental arch served as reference. PE (Impregum, 3M Oral Care) and VPS (Aquasil, Dentsply Sirona) impressions (n = 10/group) were taken with trays fabricated using different materials and manufacturing techniques (FDM: filament deposition modeling, material: Arfona Tray, Arfona; printer: Pro2, Raise3D; DLP: digital light processing, material: V-Print Tray, VOCO, printer: Max, Asiga; MPR: manual processing with light-curing plates, material: LC Tray, Müller-Omicron) including an open implant impression.
