GilOII has been unambiguously identified as the key enzyme performing the crucial C-C bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498853 | PMC |
| http://dx.doi.org/10.1021/ja3081154 | DOI Listing |
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