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Ibuprofen-induced exudative erythema multiforme after 1 week of continued therapy following oral challenge.
J Investig Allergol Clin Immunol
November 2012
Allergy Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
The in vivo effects of Flurbiprofen, Ibuprofen and Indomethacin (1.5, 6 and 3 mg/kg respectively) were studied on two acute non-specific pleurisies induced by calcium pyrophosphate crystals (CaPP) or decomplemented isologous rat serum (DIRS) in the rat. Drug effects on the exudation phase (pleural exudate volume), leukocyte emigration (number of leukocytes in the fluid) and on random and directed locomotion of elicited neutrophils (PMN) under agarose were investigated.
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