AI Article Synopsis
- The study investigated the expression of transmembrane protein 166 (TMEM166) in esophageal squamous cell carcinoma (ESCC) and nearby normal esophageal tissues to understand its potential role in tumor biology.
- Results showed that TMEM166 mRNA and protein levels were significantly lower in ESCC samples compared to normal tissues, indicating a potential decrease in its regulatory functions related to cell processes like autophagy and apoptosis.
- Despite the reduced expression of TMEM166, there was no observed correlation with tumor characteristics such as size, differentiation, stage, or lymph node metastasis.
Article Abstract
Objective: Transmembrane protein 166 (TMEM166) expression in esophageal squamous cell carcinoma (ESCC) and remote normal esophageal tissues was examined to assess any role in tumour biology.
Methods: TMEM166 mRNA expression in 36 cases with ESCC (36 tumour samples, 36 remote normal esophageal tissue samples) was detected by RT-PCR. TMEM166 protein expression was analysed in paraffin-embedded tissue samples from the same cases by immunohistochemistry.
Results: Semi-quantitative analysis showed TMEM166 mRNA expression in ESCCs to be significantly lower than in remote normal esophageal tissues (0.759 ± 0.713 vs. 2.622 ± 1.690, P=0.014). TMEM166 protein expression was also significantly reduced (69.4% vs. 94.4%, P<0.01).
Conclusion: TMEM166 mRNA and protein expression demonstrated significant reduction in ESCCs compared with remote esophageal tissues, albeit with no correlation with tumour size, differentiation, stage, and lymph node metastasis, suggesting a role in regulating autophagic and apoptotic processes in the ESCC.
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| http://dx.doi.org/10.7314/apjcp.2012.13.8.3713 | DOI Listing |
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