Positive correlation between age, leading risk factors of cardiovascular diseases (CVD), and carotid artery intima-media thickness (IMT) has been shown in numerous studies. Contingent of the present work was a part of long term cohort study initiated in 1983. We included in analysis data from 233 men in 120 of whom we measured IMT of right and left common carotid arteries. Other examinations included use of standard questionnaire for detection of CVD risk factors, measurement of blood serum lipid and glucose levels, arterial pressure, pulse, body mass and length, waist and hip circumferences (WC, HC), skin fold thicknesses on triceps, abdomen and forearm. We found that carotid artery IMT was related to hereditary load by CVD along paternal line. Substantial influence on the realization of unfavorable inheritance exerted level of systolic arterial pressure. Difference in magnitude of carotid artery IMT between groups of men with normal body mass and obesity were conditioned by variations in severity of abdominal obesity (WC/HC). IMT of carotid arteries in men directly depended on magnitude of their abdominal obesity and age.
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Ann Vasc Surg
January 2025
Vascular and Endovascular Surgery, University of Miami School of Medicine, Miami, Florida. Electronic address:
Background: Cerebral hyperperfusion syndrome (CHS) is a rare but serious complication after carotid artery revascularization. This study aims to determine the impact of carotid artery stenting (CAS) modality on the incidence, severity and overall outcomes of CHS after carotid revascularization.
Methods: Data from patients who underwent CAS with either distal embolic protection (CAS+DEP) or transcarotid artery revascularization (TCAR) were obtained from the Vascular Quality Initiative (VQI) database 2016-2023.
Food Chem Toxicol
January 2025
Department of Pharmacology, Key Laboratory of Anti-Inflammatory and Immunopharmacology of Ministry of Education, Key Laboratory of Chinese Medicine Research and Development of State Administration of Traditional Chinese Medicine, Anhui Medical University, Hefei, Anhui, People's Republic of China. Electronic address:
Ischemic stroke is a very common brain disorder. This study aims to assess the neuroprotective effects of piceatannol (PCT) in preventing neuronal injury resulting from cerebral ischemia and reperfusion (I/R) in mice. Additionally, we investigated the underlying mechanisms through which PCT inhibits neuronal ferroptosis by modulating the USP14/GPX4 signaling axis.
View Article and Find Full Text PDFImmunity
January 2025
Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance (MHA), Munich, Germany. Electronic address:
Common genetic variants in a conserved cis-regulatory element (CRE) at histone deacetylase (HDAC)9 are a major risk factor for cardiovascular disease, including stroke and coronary artery disease. Given the consistency of this association and its proinflammatory properties, we examined the mechanisms whereby HDAC9 regulates vascular inflammation. HDAC9 bound and mediated deacetylation of NLRP3 in the NACHT and LRR domains leading to inflammasome activation and lytic cell death.
View Article and Find Full Text PDFBr J Radiol
January 2025
Royal United Hospital, Combe Park, Bath, Avon, BA1 3NG, UK.
Objectives: Artificial intelligence (AI) software including Brainomix "e-CTA" which detect large vessel occlusions (LVO) have clinical potential. We hypothesised that in real world use where prevalence is low, its clinical utility may be overstated.
Methods: In this single centre retrospective service evaluation project, data sent to Brainomix from a medium size acute National Health Service (NHS) Trust hospital between 1/3/2022-1/3/2023 was reviewed.
Physiol Rep
February 2025
Department of Biomedical Engineering, Toyo University, Saitama, Japan.
The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs.
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