AI Article Synopsis
- This study examines the effects of beta-blocker Propranolol on respiratory gas levels (pH, PaO2, PaCO2) in patients with heightened bronchial sensitivity.
- The inhalation of Propranolol led to a significant drop in oxygen levels (PaO2) and a negligible rise in carbon dioxide levels (PaCO2).
- While the beta2-adrenergic stimulator Hexoprenaline provided protective effects against the drop in PaO2, the alpha2-adrenergic blocker Tolazoline did not show any protective effects against changes in respiratory gases caused by Propranolol.
Article Abstract
Introduction: This work, partial pressure of the respiratory gases in the capillary blood (pH, PaO2, PaCO2) was studied, following the protective action of the beta2-drenergic stimulator-Hexoprenaline and alpha2-adrenergic blocker-Tolazoline in the bronchoconstriction caused by a beta-blocker-Propranolol.
Material And Methods: in patients with increased bronchial reactibility. pH, oxygen partial pressure (PaO2), dioxide carbon partial pressure (PaCO2) in the arterial blood, with the assistance of the analyzer IL, following some minutes of sample taking were defined in all patients. As a standard to verify the accuracy of the measurement, ampoule solutions of pH, PaO2 and PaCO2 were utilized (Acidobasel, Berlin).
Results And Discussion: Following the inhalation of the beta-blocker-Propranolol (20 mg/ml-aerosol), there was an evident decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2. Beta2-adrenergcic stimulator-Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p < 0.05) following the bronchoconstriction being provoked by Propranolol. Alpha2-adrenergic blocker-Tolazoline (20 mg/ml-aerosol), has not shown a protective action in the bronchoconstriction caused with propranolol, therefore significant decrease (p < 0.05) of pO2 and a non-significant increase (p > 0.1) of pCO2 appeared. This shows that stimulation of beta2-adrenergic receptor has protective action in changes of the respiratory gases. Meantime, blocker of the alpha2-adrenergic receptor (Tolazoline) has not shown a protective action in changes of the respiratory gases.
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| http://dx.doi.org/10.5455/medarh.2012.66.292-295 | DOI Listing |
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