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cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling.
Sci Adv
January 2025
Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA.
Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational method, to elucidate EC transcriptomic states under low shear stress (LSS), physiological shear stress (PSS), high shear stress (HSS), and oscillatory shear stress (OSS) that induce vessel inward remodeling, stabilization, outward remodeling, or disease susceptibility, respectively. Combined with a publicly available database on EC transcriptomic responses to drug treatments, this approach inferred a regulatory network controlling EC states and made several notable predictions.
View Article and Find Full Text PDFKTED: a comprehensive web-based database for transposable elements in the Korean genome.
Bioinform Adv
November 2024
Department of Genomic Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
Summary: Transposable elements (TEs), commonly referred to as "mobile elements," constitute DNA segments capable of relocating within a genome. Initially disregarded as "junk DNA" devoid of specific functionality, it has become evident that TEs have diverse influences on an organism's biology and health. The impact of these elements varies according to their location, classification, and their effects on specific genes or regulatory components.
View Article and Find Full Text PDFMicronutrient Hunger or Hidden Hunger Among Infants and Young Children on Healthy Diets.
Nestle Nutr Inst Workshop Ser
November 2024
Parkview Family Health Care Centre, Kundara, India.
"Hidden Hunger" refers to micronutrient deficiencies that are not necessarily reflected in anthropometric measurements and thus remain hidden. It affects 2 billion people globally, and occurs among infants and young children on a "healthy diet," as perceived by family members. Hidden hunger is recognizable with a high index of suspicion and hence the term "micronutrient hunger" has been proposed.
View Article and Find Full Text PDFAndrogen Receptor and Non-Coding RNAs' Interaction in Renal Cell Carcinoma.
Noncoding RNA
November 2024
Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Renal cell carcinoma (RCC), the most prevalent among the urogenital cancers, accounts for around 3% of new cancer cases worldwide. Significantly, the incidence of RCC has doubled in developed world countries, ranking it as the sixth most common cancer in males, who represent two-thirds of RCC cases. Males with RCC exhibit a higher mortality rate and tend to develop a more aggressive form of the disease than females.
View Article and Find Full Text PDFValidating the Cattell-Braasch maneuver with a case of inherent atypical malrotation of the bowel: a case report.
J Med Case Rep
November 2024
Faculty of Medicine, Institute of Anatomy, University of Leipzig, Liebigstraße 13, 04103, Leipzig, Germany.
Background: Malrotation of the bowel due to imperfect embryologic development is a rare condition with a wide spectrum of resulting anatomical variations. Similar conditions are achieved in the adult by derotating the bowel via the Cattell-Braasch maneuver. However, possible preparational bias might compromise the resulting topography.
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