AI Article Synopsis
- Zirconocene dichloride (Cp(2)ZrCl(2)) effectively catalyzes the transamidation of primary amides with amines in cyclohexane at 80 °C, typically within 5 to 24 hours.
- The reaction can also be carried out at lower temperatures, reaching down to 30 °C, for suitable substrates.
- This process highlights the catalyst's versatility in facilitating reactions under varying thermal conditions.
Article Abstract
Zirconocene dichloride (Cp(2)ZrCl(2)) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80 °C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30 °C.
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| http://dx.doi.org/10.1039/c2cc37427g | DOI Listing |
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