Objectives: To evaluate the clinical outcomes and safety of radiofrequency (RF) ablation for benign non-functioning thyroid nodules over a 4-year follow-up.
Methods: We evaluated 126 benign non-functioning thyroid nodules of 111 patients treated with RF ablation and followed-up more than 3 years. RF ablation was performed using the Cool-Tip RF system and an internally cooled electrode. Nodule volume and cosmetic and symptom scores were evaluated before treatment and during follow-up. Complications and factors related to efficacy were evaluated.
Results: The mean follow-up duration was 49.4 ± 13.6 months. Thyroid nodule volume decreased significantly, from 9.8 ± 8.5 ml before ablation to 0.9 ± 3.3 ml (P < 0.001) at final evaluation: a mean volume reduction of 93.4 ± 11.7 %. The mean cosmetic (P < 0.001) and symptom scores (P < 0.001) improved significantly. Factors related to efficacy were initial solidity and volume. The overall recurrence rate was 5.6 % (7/126). The overall complication rate was 3.6 % (4/111).
Conclusions: RF ablation was effective in shrinking benign thyroid nodules and in controlling nodule-related problems over a 4-year follow-up. There were no life-threatening complications or sequelae. Therefore, RF ablation can be used as a non-surgical treatment for patients with benign non-functioning thyroid nodules.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00330-012-2671-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knosp and revised Knosp classifications predict non-functioning pituitary adenoma outcomes: a single tertiary center experience.
J Med Life
November 2024
Department of Endocrinology, Diabetology and Nutrition, Mohammed VI University Hospital, Medical School, Mohamed the First University, Oujda, Morocco.
Non-functioning pituitary adenomas (NFPAs) are hormonally inactive benign tumors, usually diagnosed as macro-adenoma. The aim of our research was to analyze the clinical and hormonal characteristics of NFPAs using Knosp and revised Knosp classifications. Furthermore, we aimed to assess the possibility of predicting surgical remission after surgery.
View Article and Find Full Text PDFThe not so 'simple' laparoscopic nephrectomy: Experience with 3D laparoscopy from a tertiary care centre.
Urologia
November 2024
Department of Urology, All India Institute of Medical Sciences, Jodhpur, India.
Introduction: Laparoscopic simple nephrectomy (LSNx) is among the gold standard options for management of selected poorly functioning and most non-functioning kidneys (PFK/NFKs). Our objective was to audit our patients who had undergone LSNx for benign causes and assess their perioperative outcomes and analyse the factors correlating with these outcomes.
Materials And Methods: We reviewed our prospectively collected data of patients with PFK/NFKs due to benign causes who underwent a LSNx on a three-dimensional (3D) system via a transperitoneal approach between January 2017 and June 2023.
Improving the radiological prediction of surgical resection of nonfunctioning pituitary adenomas.
J Endocrinol Invest
November 2024
Neuropathology and Molecular Genetics Laboratory, Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil.
Purpose: Nonfunctioning pituitary adenomas (NFPAs) are benign tumors growing in the sellar region. Total surgical excision of the lesion is recommended as the preferred treatment choice with preservation of adjacent structures. The objective is to establish a radiological score to predict the feasibility of NFPA total surgical excision.
View Article and Find Full Text PDFThe expression of and family genes in pituitary adenomas: clinical correlations and postsurgical outcomes.
Front Endocrinol (Lausanne)
October 2024
Post-Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão (UFMA), São Luis, Brazil.
Introduction: Pituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level. BAK1 and BAX proteins play fundamental roles in apoptosis and seem to interact with VDAC proteins, whose expressions have been markedly altered in cancer, impacting their prognosis.
View Article and Find Full Text PDFPresentation and management of patients with adrenal masses: a large tertiary centre experience.
Eur J Endocrinol
October 2024
Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham B152TT, United Kingdom.
Article Synopsis
- - The study analyzed adrenal masses in 1,397 patients at a tertiary care center from 1998 to 2022, revealing that most cases were found incidentally, with a median mass size of 2.9 cm and common diagnoses including adrenocortical adenoma, phaeochromocytoma, and adrenocortical carcinoma.
- - Following the 2016 European guidelines on adrenal incidentalomas, there was a notable decrease in the number of adrenalectomies (6.1% to 4.5%) and a significant increase in the discharge rate for patients with benign adrenal masses (4.4% to 25.3%).
- - The findings suggest that implementing these guidelines has
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!