AI Article Synopsis
- The study compared clot formation in two types of blood entry chambers (BEC) used in continuous renal replacement therapy (CRRT) for ICU patients: vertical versus horizontal designs.
- Both designs had similar circuit lifespans (13.9 hours for vertical and 17.7 hours for horizontal), but the activated partial thromboplastin time (APTT) was significantly higher for the horizontal BEC.
- Overall, there was no significant difference in clotting scores between the two chamber types, suggesting that the horizontal BEC does not reduce clotting compared to the vertical BEC.
Article Abstract
Background: The continuous renal replacement therapy (CRRT) bubble trap chamber is a frequent site of clotting.
Aims: To assess clot formation when comparing our standard 'vertical' blood entry chamber (BEC) with a new 'horizontal' BEC.
Methods: Adult ICU patients requiring CRRT were treated with the vertical BEC and then a similar subsequent cohort with the horizontal BEC in continuous veno-venous haemofiltration mode.
Results: 40 chambers were assessed for each design. Circuit life was 13.9 ± 9.5 h for the vertical and 17.7 ± 15.9 h for the horizontal BEC (p = 0.33). APTT, however, was higher for the horizontal BEC (55.7 ± 34.7 vs. 37.4 ± 9.0, p < 0.002) and no difference in circuit life was found after multivariable analysis. A clotting score ≥3 was observed in 85% of all chambers. There was no difference in chamber clotting score (vertical 3.6 ± 1.03 vs. horizontal 3.8 ± 1.0, p = 0.5). In addition, no difference was found when scores were divided into two groups using a 'likelihood' to clot analysis (p = 1.0).
Conclusion: CRRT horizontal BEC were not associated with less clotting compared to our standard vertical BEC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000342596 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and genomic characteristics of becAB-carrying Clostridium perfringens strains.
Food Microbiol
January 2025
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, China; Key Laboratory for Prevention and Control of Major Ruminant Diseases, Ministry of Agriculture and Rural Affairs, Yangling, China. Electronic address:
Article Synopsis
- Clostridium perfringens is a foodborne pathogen that causes intestinal diseases in humans and animals, especially affecting infants and young children due to its variety of toxins, including the newly identified BEC toxin.
- Recent studies identified two strains of C. perfringens carrying becAB genes in China, indicating that these strains can spread across different regions through a specific plasmid.
- This research highlights the need for continued surveillance of becAB-carrying strains due to their potential health impact and the importance of monitoring their antimicrobial resistance.
Quaternary ammonium biocides promote conjugative transfer of antibiotic resistance gene in structure- and species-dependent manner.
Environ Int
July 2024
Key Laboratory of Three Gorges Reservoir Region's Eco-environment, Ministry of Education, Chongqing University, Chongqing 400045, China.
The linkage between biocides and antibiotic resistance has been widely suggested in laboratories and various environments. However, the action mechanism of biocides on antibiotic resistance genes (ARGs) spread is still unclear. Thus, 6 quaternary ammonium biocides (QACs) with different bonded substituents or alkyl chain lengths were selected to assess their effects on the conjugation transfer of ARGs in this study.
View Article and Find Full Text PDFThe Extremely Brilliant Source storage ring of the European Synchrotron Radiation Facility.
Commun Phys
April 2023
ESRF - The European Synchrotron, 71 Avenue des Martyrs, 38000 Grenoble, France.
The Extremely Brilliant Source (EBS) is the experimental implementation of the novel Hybrid Multi Bend Achromat (HMBA) storage ring magnetic lattice concept, which has been realised at European Synchrotron Radiation Facility. We present its successful commissioning and first operation. We highlight the strengths of the HMBA design and compare them to the previous designs, on which most operational synchrotron X-ray sources are based.
View Article and Find Full Text PDFHorizontal connectivity in V1: Prediction of coherence in contour and motion integration.
PLoS One
July 2022
NeuroPSI-UNIC, Paris-Saclay Institute of Neuroscience, CNRS, Paris-Saclay University, Gif-sur-Yvette, France.
This study demonstrates the functional importance of the Surround context relayed laterally in V1 by the horizontal connectivity, in controlling the latency and the gain of the cortical response to the feedforward visual drive. We report here four main findings: 1) a centripetal apparent motion sequence results in a shortening of the spiking latency of V1 cells, when the orientation of the local inducer and the global motion axis are both co-aligned with the RF orientation preference; 2) this contextual effects grows with visual flow speed, peaking at 150-250°/s when it matches the propagation speed of horizontal connectivity (0.15-0.
View Article and Find Full Text PDFAnalysis of the complete genome sequences of Clostridium perfringens strains harbouring the binary enterotoxin BEC gene and comparative genomics of pCP13-like family plasmids.
BMC Genomics
March 2022
Department of Bacterial Infection, Research Institute for Microbial Disease (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Background: BEC-producing Clostridium perfringens is a causative agent of foodborne gastroenteritis. It was first reported in 2014, and since then, several isolates have been identified in Japan and the United Kingdom. The novel binary ADP-ribosylating toxin BEC, which consists of two components (BECa and BECb), is encoded on a plasmid that is similar to pCP13 and harbours a conjugation locus, called Pcp, encoding homologous proteins of the type 4 secretion system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!