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Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA. | LitMetric
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Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.

Benoit Visseaux Charlotte Charpentier Audrey Taieb Florence Damond Antoine Bénard Lucile Larrouy Geneviève Chêne Françoise Brun-Vézinet Sophie Matheron Diane Descamps

AIDS

Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris AP-HP, Groupe Hospitalier Bichat-Claude Bernard, HUPNVS, Université Paris Diderot, Paris 7, PRES Sorbonne Paris Cité, Paris, France.

Published: January 2013

In this study, assessing HIV-2 tropism among 43 paired plasma/peripheral blood mononuclear cell specimens, the concordance between proviral DNA and plasma RNA genotypic tropism prediction was 74%. All the discordances were attributable to the prediction of R5 in RNA and X4/dual-mixed in DNA. HIV-2 genotypic tropism test based on proviral DNA is a suitable tool for tropism determination in HIV-2-infected patients with low or undetectable viral load.

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http://dx.doi.org/10.1097/QAD.0b013e32835b8bbdDOI Listing

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