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Non-Viral Systems Based on PAMAM-Calix-Dendrimers for Regulatory siRNA Delivery into Cancer Cells.
Int J Mol Sci
November 2024
A.M. Butlerov Chemistry Institute, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, Russia.
Cancer is one of the most common diseases in developed countries. Recently, gene therapy has emerged as a promising approach to cancer treatment and has already entered clinical practice worldwide. RNA interference-based therapy is a promising method for cancer treatment.
View Article and Find Full Text PDFUnusually Rapid Isomerization of Aspartic Acid in Tau.
bioRxiv
December 2024
Department of Chemistry, University of California, Riverside, California 92521, United States.
Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins.
View Article and Find Full Text PDFTroponin Test, Not Only a Number: An Unusual Case of False Positive.
Int J Mol Sci
November 2024
UOC Laboratory of Clinical Medicine with Specialized Areas, IRCCS MultiMedica Hospital, 20138 Milan, Italy.
Heterophile antibodies, which can arise from infections, autoimmune disorders, or exposure to animal antigens, can interfere with immunoassays. These antibodies can cross-react with the test reagents used in troponin assays, causing a false elevation in troponin levels. The paper describes a case of a 37-year-old male drug abuser admitted to the emergency room with chest pain.
View Article and Find Full Text PDFAdditives in Processed Foods as a Potential Source of Endocrine-Disrupting Chemicals: A Review.
J Xenobiot
November 2024
Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Article Synopsis
- Processed foods are loaded with food additives that enhance flavor, texture, and shelf life, but many of these additives can act as endocrine-disrupting chemicals (EDCs).
- EDCs can interfere with hormone regulation and cause health issues like obesity, diabetes, and reproductive problems, as well as developmental abnormalities.
- The review seeks to identify harmful food additives, explore their uses in the food industry, and propose strategies for reducing such additives in favor of safer alternatives to safeguard human health.
Evidence for correlated electron pairs and triplets in quantum Hall interferometers.
Nat Commun
November 2024
Univ. Grenoble Alpes, CNRS, Grenoble INP, Institut Néel, Grenoble, France.
The pairing of electrons is ubiquitous in electronic systems featuring attractive inter-electron interactions, as exemplified in superconductors. Counterintuitively, it can also be mediated in certain circumstances by the repulsive Coulomb interaction alone. Quantum Hall (QH) Fabry-Pérot interferometers (FPIs) tailored in a two-dimensional electron gas under a perpendicular magnetic field have been argued to exhibit such an unusual electron pairing, seemingly without attractive interactions.
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