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Brain tissue integrity in neuromyelitis optica spectrum disorder through T1-w/T2-w ratio, MTR and DTI.
J Neurol
January 2025
Department of Radiology and Oncology, Instituto de Radiologia. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Rua Dr. Ovídio Pires de Campos, 75, Cerqueira César, São Paulo, 05403010, Brazil.
Background: The presence of diffuse brain damage in normal-appearing white matter (NAWM) and gray matter (NAGM) in neuromyelitis optica spectrum disorder (NMOSD) remains controversial. We aimed to address this controversy by applying a multiparametric MRI approach. Additionally, the association between MRI metrics and clinical variables was explored.
View Article and Find Full Text PDFAnti-nucleocapsid SARS-CoV-2 antibody seroprevalence in previously infected persons with immunocompromising conditions-United States, 2020-2022.
PLoS One
January 2025
Office of Public Health Data, Surveillance and Technology, US Centers for Disease Control, Atlanta, Georgia, United States of America.
People with immunocompromising conditions (IC) are at increased risk of severe COVID-19 and death. These individuals show weaker immunogenicity following vaccination than individuals without IC, yet immunogenicity after SARS-CoV-2 infection is poorly understood. To address this gap, the presence of infection-induced antibodies in sera following a positive COVID-19 test result was compared between patients with and without IC.
View Article and Find Full Text PDFFrom immune dysregulation to organ dysfunction: understanding the enigma of Sepsis.
Front Microbiol
August 2024
Department of Infectious Disease, Graduate Collaborative Training Base of Zhuzhou, Hengyang Medical School, University of South China, Hengyang, China.
Sepsis is a syndrome precipitated by immune dysregulation in response to infection, and represents a pivotal factor in global mortality attributed to diseases. The recent consensus delineates sepsis as a perilous state of organ dysfunction arising from the host's maladaptive reaction to infection. It masks the complexity and breadth of the immune mechanisms involved in sepsis, which is characterized by simultaneous hyperinflammation and immunosuppression.
View Article and Find Full Text PDFUnexpected high incidence of parvovirus B19 nucleic acid detection in German blood donors in the winter/spring season 2023/2024.
J Med Virol
September 2024
Institut für Laboratoriums- und Transfusionsmedizin, Herz-und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Medizinische Fakultät OWL (Universität Bielefeld), Bad Oeynhausen, Germany.
Article Synopsis
- Parvovirus B19 usually causes mild sickness in healthy adults but can be serious for people with weak immune systems or high red blood cell production.
- Between 2015 and April 2024, over 2 million blood donations in Germany were tested for PVB19, leading to the discovery of 242 positive cases.
- During the COVID-19 pandemic, strict hygiene like wearing masks helped reduce PVB19 infections, but after the pandemic, the number of cases started to rise again.
Cyclophosphamide exposure factors in family caregivers for pediatric cancer patients.
Int J Hyg Environ Health
July 2024
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Article Synopsis
- * Urine analysis showed that 27% of family caregivers had detectable levels of CPM, peaking 24 to 48 hours after the drug was administered to patients, indicating significant exposure risks.
- * The findings emphasize that care activities requiring physical contact, particularly emotional support, correlate with increased CPM contamination on personal protective equipment (PPE), suggesting that diligent PPE use is crucial, especially within 48 hours post-treatment.
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