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Contact Cooling-Induced ELOVL4 Enhances Skin Wound Healing by Promoting the Inflammation-to-Proliferation Phase Transition.
Int J Biol Sci
March 2025
111 Project Laboratory of Biomechanics and Tissue Repair & Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Empirical evidence indicates that the rate of wound healing varies through different seasons, where it is higher in spring and fall but lower in summer and winter, suggesting adequate temperatures may promote wound healing via an unknown mechanism. Here we show that adequate temperature facilitates wound healing by inducing the expression of Elongation of Very Long Chain Fatty Acid Elongase 4 (ELOVL4) that curtails the inflammation phase. Using skin injury and skin organoids models, bulk- and single-cell RNA-sequencing and spatial transcriptomics analysis, and functional perturbations, we first demonstrate that adjusting skin surface temperature to 20°C by contact cooling markedly increases the rate of wound healing via upregulating ELOVL4 in the injured epidermis.
View Article and Find Full Text PDFBrain functional connectivity changes on fMRI in patients with chronic pelvic pain treated with the Neuro Emotional Technique: a randomised controlled trial.
J Obstet Gynaecol
December 2025
Department of Integrative Medicine and Nutritional Sciences, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Background: Chronic pelvic pain is a substantial clinical challenge that profoundly impacts quality of life for many women. The Neuro Emotional Technique (NET) is a novel mind-body intervention designed to attenuate emotional arousal of distressing thoughts and pain. This study evaluated functional connectivity changes in key areas of the brain in patients with chronic pelvic pain receiving the NET intervention.
View Article and Find Full Text PDFIs cone beam computed tomography accurate in predicting inferior alveolar nerve exposure during mandibular third molar extraction?
BMC Oral Health
March 2025
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry, Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, P.R. China.
Objectives: This study aims to evaluate the accuracy of cone beam computed tomography (CBCT) in predicting the exposure of inferior alveolar nerve (IAN) during complicated mandibular third molars (M3M) extraction.
Methods: 115 M3Ms with canal cortical defect signs on preoperative CBCT were extracted. Candidate variables included sex, age, types of CBCT machine, the Winter classification of M3Ms, the size of root entering the canal on CBCT, the size of cortical defect on CBCT.
Increasing Trends of Pediatric Thoracic and Lumbar Spine Fractures in the United States from 2004 to 2023: A 20-year National Injury Review Depicting Shifts in Mechanisms of Injury.
Clin Orthop Relat Res
February 2025
Lerner Children's Pavilion, Hospital for Special Surgery, New York, NY, USA.
Background: Fractures of the thoracic and lumbar spine are uncommon injuries in children and adolescents, but they carry substantial morbidity and a real risk of death. Compared with the adult spine, the pediatric spine has unique anatomic and biomechanical properties that yield different fracture patterns than the adult population. The mechanisms of injury and degree of skeletal maturity constitute important predictors of the outcomes of pediatric thoracic and lumbar fractures; however, there remains a paucity of meaningful epidemiologic data with specific attention to the pediatric spine.
View Article and Find Full Text PDF[Characterization of occupational exposure to high temperatures based on regional ecological data. Argentina, 2005-2023].
Arch Prev Riesgos Labor
October 2024
, Argentina.
Objective: Exposure to high temperatures was evaluated with regional climate data provided by the National Meteorological Service, applying occupational exposure parameters. Methods: The provinces were characterized during 2005-2023 with maximum, average and minimum temperatures, and daily humidity percentages. Days with dangerous temperatures were defined as 28ºC and 90% humidity.
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