2-Arylbenzofuran and tyrosinase inhibitory constituents of Morus notabilis.

J Asian Nat Prod Res

Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.

Published: February 2013

AI Article Synopsis

  • Researchers isolated and identified 10 compounds from the stem of Morus notabilis, focusing on 2-arylbenzofurans.
  • Two new compounds were discovered during this investigation: (1) a dihydro-bibenzofuran-6,4'-diol and (2) a methoxyphenyl-benzofuran.
  • Moracins O and P were found to effectively inhibit mushroom tyrosinase, outperforming kojic acid in potency (IC₅₀ values).

Article Abstract

Phytochemical investigation of the stem of Morus notabilis led to the isolation and characterization of 10 compounds of 2-arylbenzofurans (1-10), including two new compounds, (2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-2,6'-bibenzofuran-6,4'-diol (1) and 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (2). Moracins O (6) and P (10) showed inhibitory effects on mushroom tyrosinase with IC₅₀ values being lower than that of kojic acid.

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http://dx.doi.org/10.1080/10286020.2012.724400DOI Listing

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