The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3785/j.issn.1008-9292.2012.05.019 | DOI Listing |
Publication Analysis
Top Keywords
[research progress
4
progress protein
4
protein tyrosine
4
tyrosine phosphatase
4
phosphatase shp-2]
4
shp-2] src
4
src homology-2
4
homology-2 domain-containing
4
domain-containing phosphatase
4
phosphatase shp-2
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!