Background: Fast analysis of chemicals in samples of complex mixtures is important for many analytical applications including therapeutic drug monitoring and food safety screening.
Methods: Based on the paper spray technology developed recently, a high throughput device was developed in this work and used for evaluation of the fast quantitative analysis using paper spray mass spectrometry.
Results: The performance of the method was characterized with bovine blood samples spiked with sunitinib and nicotine. At optimized condition, relatively fast analysis speed of 7s/sample was achieved with relatively good LOQs (1 ng/ml) and quantitation.
Conclusion: In an application of the method for food screening, LODs better than 1 ng/g were achieved for clenbuterol in beef.
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| http://dx.doi.org/10.1016/j.cca.2012.10.025 | DOI Listing |
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