Objective: To investigate whether season of birth is associated with celiac disease (CD).
Study Design: We performed a medical record review of 1964 patients with biopsy-proven CD at 3 teaching hospitals (2 pediatric centers and 1 adult center) between 2000 and 2010. The first positive small intestinal biopsy result defined age of diagnosis. The observed proportions of births in each season (spring [March-May], summer [June-August], fall [September-November], and winter [December-February]) were compared with the expected proportions using binomial probability tests.
Results: The mean age at diagnosis was 9.8 ± 5.0 years in the 2 pediatric centers and 43.6 ± 15.8 years in the adult center. The cohort was predominately female (69%). Overall, more patients were born in spring (27%) than in any other season: summer (25%), fall (25%), and winter (23%). In patients diagnosed before age 15 years, the spring birth excess was present in boys (33%; P = .0005), but not in girls (26%; P = .43). The sex difference in season of birth was less striking in patients with CD diagnosed at age ≥15 years.
Conclusion: Season of birth is an environmental risk factor for CD, particularly in boys diagnosed before age 15 years. The results are consistent with a new theoretical model that integrates potential environmental factors (eg, gluten introduction, ultraviolet-B exposure, vitamin D status) and acute viral gastrointestinal infections in early childhood.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpeds.2012.08.056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relative age effects in ice hockey extends to coaching.
Front Sports Act Living
January 2025
Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Date of birth influences the chances of success in sports. Compared to players born just before a cutoff date for marking the admissibility in a category (age groups), players born soon after are overrepresented. However, it is not yet known whether the effect of date of birth in sports applies beyond the players' active participation in the game.
View Article and Find Full Text PDFInfluenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes.
Vaccines (Basel)
January 2025
Airway Research Center North, German Center of Lung Research (DZL), 23562 Lübeck, Germany.
Background: Very-low-birth-weight infants (VLBWIs; birth weight < 1500 g) are at an increased risk of complicated influenza infection, which frequently includes pneumonia, encephalitis or even death. Data on influenza immunization and its outcome in VLBWIs are scarce. This study aimed to provide epidemiological data on influenza immunization for German VLBWIs and hypothesized that immunization would protect VLBWIs from infection-mediated neurodevelopmental impairment and preserves lung function at early school age.
View Article and Find Full Text PDFShort communication: The importance of random effects in detecting purging of inbreeding depression: A model comparison in Pannon White rabbits.
Animal
December 2024
Institute of Animal Sciences, Hungarian University of Agriculture and Life Sciences Institution, 40, Guba S. str., H-7400 Kaposvár, Hungary.
Inbreeding depression (ID) is a well-documented phenomenon associated with reduced fitness and possible extinction. However, ID can be mitigated or even eliminated through the interplay of inbreeding and selection, a process known as purging. The aim of this study was to compare the predictive power of two commonly used approaches in models with and without random dam effects to detect purging (full and reduced models).
View Article and Find Full Text PDFClinical findings of candidate stallions presented for licensing at all German Warmblood horse-breeding associations in 2018-2020.
Equine Vet J
January 2025
Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany.
Background: There is very little information available about the health status of young stallions from the German Warmblood population that will, once licensed, shape the future of equestrian sport and horse breeding.
Objectives: To evaluate the prevalence of clinical findings at licensing examinations of candidate stallions and the influences of season of birth, age at licensing, year of licensing, and the evaluator on the distribution of recorded findings.
Study Design: Retrospective observational study.
Bat Viral Shedding: A Review of Seasonal Patterns and Risk Factors.
Vector Borne Zoonotic Dis
January 2025
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Bats act as reservoirs for a variety of zoonotic viruses, sometimes leading to spillover into humans and potential risks of global transmission. Viral shedding from bats is an essential prerequisite to bat-to-human viral transmission and understanding the timing and intensity of viral shedding from bats is critical to mitigate spillover risks. However, there are limited investigations on bats' seasonal viral shedding patterns and their related risk factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!