Memories are remarkably persistent, but rely on transient signaling. The prion-like properties of CPEB suggested a solution to this problem. The paper by Krüttner et al. (2012) in this issue of Neuron demonstrates that the prion-like domain of Drosophila CPEB functions independently of its RNA-binding domain for memory.
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| http://dx.doi.org/10.1016/j.neuron.2012.10.001 | DOI Listing |
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Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.
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Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:
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Department of Cellular and Structural Biology, UT Health San Antonio, San Antonio, TX 78229, USA.
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LSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
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