AI Article Synopsis
- The marine environment, particularly the sponge diversity in Papua New Guinea, is a promising yet underexplored source for discovering new natural products for drug development.
- Many natural products from PNG sponges, noted for their biological activity, show potential as drugs and are undergoing clinical trials.
- The study highlights that these bioactive compounds likely originate from microbial processes, specifically non-ribosomal peptide and polyketide biosynthesis, involving symbiotic relationships between sponges and their microbial partners.
Article Abstract
The discovery of novel natural products for drug development relies heavily upon a rich biodiversity, of which the marine environment is an obvious example. Marine natural product research has spawned several drugs and many other candidates, some of which are the focus of current clinical trials. The sponge megadiversity of Papua New Guinea is a rich but underexplored source of bioactive natural products. Here, we review some of the many natural products derived from PNG sponges with an emphasis on those with interesting biological activity and, therefore, drug potential. Many bioactive natural products discussed here appear to be derived from non-ribosomal peptide and polyketide biosynthesis pathways, strongly suggesting a microbial origin of these compounds. With this in mind, we also explore the notion of sponge-symbiont biosynthesis of these bioactive compounds and present examples to support the working hypothesis.
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| http://dx.doi.org/10.1002/cbdv.201100292 | DOI Listing |
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