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Lycopene supplementation reduces inflammatory, histopathological and DNA damage in an acute lung injury rabbit model.
Crit Care Sci
January 2025
Department of Physical Therapy, Universidade Federal de Uberlândia - Uberlândia (MG), Brazil.
Objective: To investigate the effects of lycopene supplementation on inflammation, lung histopathology and systemic DNA damage in an experimentally induced lung injury model, ventilated by conventional mechanical ventilation and high-frequency oscillatory ventilation, compared with a control group.
Methods: Fifty-five rabbits sampled by convenience were supplemented with 10mg/kg lycopene for 21 days prior to the experiment. Lung injury was induced by tracheal infusion of warm saline.
Hilbert transform analysis of the mouse scotopic electroretinogram reveals two distinct bursts of oscillatory potentials with progressively dimmer flashes.
Doc Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Research Institute of the McGill University Health Centre/Montreal Children's Hospital, 1001 Décarie Boulevard, Glen Site, Block E, Office #EM03238, Montréal, QC, H4A 3J1, Canada.
Purpose: Study the scotopic oscillatory potentials (OPs) in mice over a wide range of flash luminance levels using the Hilbert transform (HT) to extract new features of the high frequency components of the electroretinogram (ERG).
Methods: Scotopic ERGs [Intensity: - 6.3 to 0.
Changes in the Spatial Structure of Synchronization Connections in EEG During Nocturnal Sleep Apnea.
Clocks Sleep
December 2024
Institute of Physics, Saratov State University, Astrahanskaia, 83, Saratov 410012, Russia.
This study involved 72 volunteers divided into two groups according to the apnea-hypopnea index (AHI): AHI>15 episodes per hour (ep/h) (main group, n=39, including 28 men, median AHI 44.15, median age 47), 0≤AHI≤15ep/h (control group, n=33, including 12 men, median AHI 2, median age 28). Each participant underwent polysomnography with a recording of 19 EEG channels.
View Article and Find Full Text PDFPallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in A Rat Model of Parkinsonian.
J Neurosci
January 2025
Department of Biomedical Engineering, Michigan Technological University, 1400 Townsend Dr. Houghton, MI 49931.
Deep brain stimulation (DBS) effectively treats motor symptoms of advanced Parkinson's disease (PD), with the globus pallidus interna (GPi) commonly targeted. However, its therapeutic mechanisms remain unclear. We employed optogenetic stimulation in the entopeduncular nucleus (EP), the rat homologue of GPi, in a unilateral 6-OHDA lesioned female Sprague Dawley rat model of PD.
View Article and Find Full Text PDFManagement of traumatic brain injury and acute respiratory distress syndrome-What evidence exists? A scoping review.
J Intensive Care Soc
January 2025
Critical Care and Perioperative Population Health Research (CAPER) Program, Department of Anesthesiology, Duke University, Durham, NC, USA.
Introduction: Up to 20% of patients with traumatic brain injury (TBI) develop acute respiratory distress syndrome (ARDS), which is associated with increased odds of mortality. Guideline-based treatment for ARDS includes "lung protective" ventilation strategies, some of which are in opposition to "brain protective" strategies used for ventilation with patients with TBI. We conducted a scoping review of ventilation management strategies with clinical outcomes among patients with TBI and ARDS.
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