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Comparing budesonide treatment in eosinophilic esophagitis: a specialized center cohort versus a population-based cohort.
Scand J Gastroenterol
December 2024
The Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Article Synopsis
- - The study analyzed treatment differences for eosinophilic esophagitis (EoE) between patients at specialized centers (EoE-Cph cohort) and a broader population (DanEoE cohort), focusing on pre-treatment practices, follow-up, and remission rates during budesonide treatment.
- - Results showed that while a higher percentage of DanEoE patients were on proton pump inhibitors before starting treatment, follow-up rates post-treatment were also more consistent in this group; however, histologic follow-up rates after treatment were similar between both cohorts.
- - The authors concluded that there wasn't enough evidence to recommend treating EoE exclusively at specialized centers, pointing out issues with conflicting responses to treatment and the impact
DiffuseRT: predicting likely anatomical deformations of patients undergoing radiotherapy.
Phys Med Biol
July 2024
Paul Scherrer Institute, Center for Proton Therapy, Villigen, Switzerland.
. Predicting potential deformations of patients can improve radiotherapy treatment planning. Here, we introduce new deep-learning models that predict likely anatomical changes during radiotherapy for head and neck cancer patients.
View Article and Find Full Text PDFNETest in advanced high-grade gastroenteropancreatic neuroendocrine neoplasms.
J Neuroendocrinol
November 2024
Department of Oncology, Copenhagen University Hospital - Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Molecular blood biomarkers are lacking for high-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN). To histologically distinguish between neuroendocrine carcinoma (NEC), neuroendocrine tumors G3 (NET G3), adenocarcinoma and MINEN is often challenging. The mRNA-based NETest has diagnostic, prognostic and predictive value in neuroendocrine tumors G1-2 but has not been studied in HG GEP-NEN.
View Article and Find Full Text PDFRobustness of intensity modulated proton treatment of esophageal cancer for anatomical changes and breathing motion.
Radiother Oncol
September 2024
Department of Radiation Oncology (MAASTRO), GROW-School for Oncology, Maastricht University Medical Center, Maastricht, the Netherlands.
Background And Purpose: In this study, we assessed the robustness of intensity modulated proton therapy (IMPT) in esophageal cancer for anatomical variations during treatment.
Methods: The first sixty esophageal cancer patients, treated clinically with chemoradiotherapy were included. The treatment planning strategy was based on an internal target volume (ITV) approach, where the ITV was created from the clinical target volumes (CTVs) delineated on all phases of a 4DCT.
Patients with eosinophilic oesophagitis in Denmark have higher use of psychotropic drugs: A Danish nationwide study of psychotropic drug use in 3367 patients and 16,835 matched comparators.
United European Gastroenterol J
June 2024
Department of Emergency Medicine and Trauma Center, Aalborg University Hospital, Aalborg, Denmark.
Background: Eosinophilic oesophagitis (EoE) is a chronic, immune-mediated disease of the oesophagus. Eosinophilic oesophagitis is associated with a substantial disease burden affecting the quality of life and affecting mental health. There are limited data describing the incidence of psychiatric disorders and the use of psychotropic drugs (PDs) in EoE patients.
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