Constitutionally tall stature (CTS) in children is a normal variant of growth within populations. Based mainly on psychological factors, sex steroids have been prescribed since the 1950s to induce puberty, as a mean to reduce final adult height. Controversy remains in the treatment of CTS, as well as lack of established criteria for initiating treatment. We report a constitutionally tall Saudi boy who was treated with sex steroids and was successful in reducing his final adult height.
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http://dx.doi.org/10.1136/bcr-2012-006636 | DOI Listing |
Arch Dis Child
March 2018
Department of Orthopaedic Surgery, Catharina Hospital, Eindhoven, The Netherlands.
Context: Percutaneous epiphysiodesis (PE) around the knee to reduce predicted excessive final height. Studies until now included small numbers of patients and short follow-up periods.
Objective And Design: This Dutch multicentre, long-term, retrospective, follow-up study aimed to assess adult height (AH), complications, knee function and patient satisfaction after PE.
Pediatr Res
November 2016
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Background: Reduction of adult height by sex steroid treatment was introduced decades ago in tall statured children, but controlled trials are lacking and treatment is controversial. In this study, we wanted to evaluate the phenotypic characteristics in girls referred due to tall stature and the effect of oral administration of 17β-estradiol on predicted adult height in girls.
Methods: A single-centre retrospective observational study of 304 girls evaluated consecutively due to tall stature between 1993 and 2013.
Eur J Hum Genet
August 2016
Department of Genetics, Assistance Publique - Hôpitaux de Paris (AP-HP) - Robert Debré University Hospital, Paris, France.
Noonan syndrome is a heterogeneous autosomal dominant disorder caused by mutations in at least eight genes involved in the RAS/MAPK signaling pathway. Recently, RIT1 (Ras-like without CAAX 1) has been shown to be involved in the pathogenesis of some patients. We report a series of 44 patients from 30 pedigrees (including nine multiplex families) with mutations in RIT1.
View Article and Find Full Text PDFQJM
April 2013
Center for Health, Exercise and Sport Sciences, Stari DIF, Belgrade, Serbia.
Background: Although the accuracy of final height prediction using skeletal age development has been confirmed in many studies for children treated for congenital primary hypothyroidism, short normal children, constitutionally tall children, no studies compared the predicted adult height at young age with final stature in athletic population.
Aim: In this study, the intention was to investigate to what extent the Tanner-Whitehouse (TW) method is adequate for prediction of final stature in young Caucasian male athletes.
Design: Prospective observational study.
BMJ Case Rep
October 2012
Department of Pediatrics, National Guard Health Affairs, Riyadh, Saudi Arabia.
Constitutionally tall stature (CTS) in children is a normal variant of growth within populations. Based mainly on psychological factors, sex steroids have been prescribed since the 1950s to induce puberty, as a mean to reduce final adult height. Controversy remains in the treatment of CTS, as well as lack of established criteria for initiating treatment.
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