We previously demonstrated that manifestation of gastroprotective or proulcerogenic effects of single dexamethasone injection depends on duration of the hormonal action before ulcerogenic stimulus, but not on the hormonal dose. In the present study we investigated dose and time dependence of corticosterone and cortisol effects on the gastric erosion in rats in comparative aspect with dexamethasone effects. Gastric erosion was induced by indomethacin (35 mg/kg, sc) in preliminary fasted rats. Single injection of corticosterone or cortisol at the doses of 25, 50, 100 mg/kg one hour before indomethacin administration resulted in dose dependent gastroprotective effects similar to dexamethasone effects. However, after extending the hormonal action till 24 h (before indomethacin administration), the gastroprotective effect of corticosterone (100 mg/kg) and cortisol (50 mg/kg) didn't transform into a proulcerogenic one, in contrast to dexamethasone, but simply disappeared. The absence of long-lasting corticosterone deficiency in blood after corticosterone and cortisol injection, which was observed after dexamethasone injection, could be at least one of the possible reasons for the absence of transformation of the gastroprotective action of corticosterone and cortisol to a proulcerogenic one.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Acute and chronic cannabis vapor exposure influences basal and stress-induced release of glucocorticoids in male and female rats.
Psychoneuroendocrinology
December 2024
Hotchkiss Brain Institute, Mathison Centre for Mental Health Research and Education, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; Department of Cell Biology and Anatomy & Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:
Management of stress and anxiety is often listed as the primary motivation behind cannabis use. Human research has found that chronic cannabis use is associated with increased basal cortisol levels but blunted neuroendocrine responses to stress. Preclinical research has demonstrated mixed effects of Δ-tetrahydrocannabinol (THC; the psychoactive constituent of cannabis), much of which is suggestive of dose-dependent effects; however, the predominance of this work has employed an injection method to deliver cannabis.
View Article and Find Full Text PDFGut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.
Gut Microbes
December 2025
Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. However, the causal relationship and key factors between gut dysbiosis and brain disorders in chronic stress remain elusive, particularly under non-sterile conditions.
View Article and Find Full Text PDFSex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.
Cells
December 2024
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), Institute of Mental Health and Drug Discovery, School of Mental Health, Wenzhou Medical University, Ouhai District, Wenzhou 325000, China.
Background: glucocorticoids may play an important role in the formation of fear memory, which is relevant to the neurobiology of post-traumatic stress disorder (PTSD). In our previous study, we showed the glucocorticoid receptor (GR) forms a protein complex with FKBP51, which prevents translocation of GR into the nucleus to affect gene expression; this complex is elevated in PTSD patients and by fear-conditioned learning in mice, and disrupting this complex blocks the storage and retrieval of fear-conditioned memories. The timing of release of glucocorticoid relative to the formation of a traumatic memory could be important in this process, and remains poorly understood.
View Article and Find Full Text PDFSteroid hormone concentrations in dried blood spots: A comparison between capillary and venous blood samples.
Clin Chim Acta
February 2025
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Location University of Amsterdam, Amsterdam Gastroenterology Endocrinology & Metabolism, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam Gastroenterology Endocrinology & Metabolism, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Location University of Amsterdam, Amsterdam Reproduction & Development, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands. Electronic address:
Background: An important aspect of the shift towards dried blood spots (DBS) as a sample matrix for laboratory measurements, is the availability of robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods that can reliably quantify analyte concentrations in DBS. The development and validation of these LC-MS/MS methods, however, concerns an extensive process, for which large amounts of DBS samples are required. DBS are usually obtained from capillary blood samples, but they can also be prepared from venous (residual) blood samples, which are widely available in clinical laboratories.
View Article and Find Full Text PDFCracking the code of aldosterone synthase deficiency: bridging genetics and biochemistry: a case report.
Lab Med
December 2024
Department of Pediatrics, AIIMS Patna, Patna, Bihar, India.
Objective: Aldosterone synthase deficiency (ASD) is a rare autosomal recessive inherited disease with an overall clinical phenotype of failure to thrive, vomiting, severe dehydration, hyperkalemia, and hyponatremia. Mutations in the CYP11B2 gene encoding AS are responsible for the occurrence of ASD. Defects in CYP11B2 gene have only been reported in a limited number of cases worldwide.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!