Acute lymphoblastic leukemia (ALL), CD10+ B-cell precursor, represents the most frequent type of childhood ALL from 3 to 6 years of age. The t(12;21)(p13;q22) occurs in 25% of cases of B-cell precursor ALL, it is rare in children less than 24 months and have been related to good prognosis. Some relapse cases and unfavorable prognosis in ALL CD10+ are associated with t(12;21) bearing additional aberrations as extra copies of chromosome 21 and ETV6 gene loss. This report describes the case of a 15 month-year old girl, who displayed a karyotype with addition on chromosome 12p plus trisomy 10 and tetrasomy of chromosome 21. Molecular cytogenetic studies revealed two extra copies of the der(21) t(12;21), trisomy 10 and deletion of the second ETV6 gene due to the dic(12;18). These findings show the great importance of molecular cytogenetic studies to clarify complex karyotypes, to define prognostic, to carry out risk group stratification and to support correctly disease treatment in childhood acute lymphoblastic leukemia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447226 | PMC |
| http://dx.doi.org/10.1155/2012/186532 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Architecture and Assembly of Structurally Complex Viruses.
Subcell Biochem
December 2024
Department of Macromolecular Structure, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain.
Viral particles consist essentially of a proteinaceous capsid that protects the genome and is also involved in many functions during the virus life cycle. In structurally simple viruses, the capsid consists of a number of copies of the same, or a few different proteins organized into a symmetric oligomer. Structurally complex viruses present a larger variety of components in their capsids than simple viruses.
View Article and Find Full Text PDFInability of Ogataea parapolymorpha pho91-Δ mutant to produce active methanol oxidase can be compensated by inactivation of the PHO87 gene.
Folia Microbiol (Praha)
December 2024
Federal Research Center "Pushchino Scientific Center for Biological Research", Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Russian Federation.
Cells of the methylotrophic yeast Ogataea parapolymorpha have two genes encoding low-affinity phosphate transporters: PHO87, encoding the plasma membrane transporter, and PHO91, encoding a protein, which is homologous to the Saccharomyces cerevisiae vacuolar membrane transporter. Earlier, we reported that inactivation of PHO91 in O. parapolymorpha interferes with methanol utilization due to the lack of activity of methanol oxidase encoded by the MOX gene.
View Article and Find Full Text PDFQuantitative real-time PCR analysis of gut microbiota in rheumatoid arthritis patients compared to healthy controls.
AMB Express
December 2024
Department of Medical Microbiology and Immunology, Faculty of Medicine, Shahrekord Medical University, Shahrekord, Iran.
Rheumatoid arthritis (RA) is an autoimmune disorder with synovial inflammation of joints and extra articular manifestations. The results of recent researches consider the relationship between microbiota and the immune system as a double-edged sword. Considering that the relationship between the composition of intestinal microbiota and the immunological and clinical status of the body has been confirmed, it is very important to investigate the effect of each genus and species of bacteria on the state of the immune system.
View Article and Find Full Text PDFA Graph-based Goat Pangenome Reveals Structural Variations Involved in Domestication and Adaptation.
Mol Biol Evol
December 2024
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Pangenomes can facilitate a deeper understanding of genome complexity. Using de novo phased long-read assemblies of eight representative goat breeds, we constructed a graph-based pangenome of goats (Capra hircus) and discovered 113-Mb autosomal novel sequences. Combining this multi-assembly pangenome with low-coverage PacBio HiFi sequences, we constructed a long-read structural variations (SVs) database containing 59,325 SV deletions, 84,910 SV insertions, and 24,954 other complex SV alleles.
View Article and Find Full Text PDFNanozymes featuring a mesoporous silica shell for rapid enrichment and ultrasensitive lateral flow immunoassay of influenza A.
Anal Chim Acta
January 2025
Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China. Electronic address:
Background: Respiratory illnesses stemming from influenza A viruses represent a significant worldwide health concern. There is an immediate need for a rapid and sensitive method to detect influenza A viruses early, without requiring extra equipment.
Results: Here, we established a lateral flow immunoassay (LFIA) for the detection of influenza A (Flu A) using a "three-in-one" multifunctional mesoporous FeO@SiO@Pt nanozymes (FeO@MSiO@Pt NZs) with excellent magnetic separation properties, colorimetric, and peroxidase-like (POD-like) activities.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!