AI Article Synopsis
- The first case of porcine pandemic influenza A (H1N1) 2009 virus was reported in Norway in October 2009, indicating potential human-to-pig virus transmission.
- Unusual lung lesions were found in infected fattening pigs, characterized by specific patterns of consolidation in the lungs.
- Histopathological analysis confirmed infection, showing signs of epithelial damage and lymphocyte infiltration, similar to findings in other influenza A virus infections in pigs.
Article Abstract
The Norwegian pig population was considered free from influenza A virus infections until the first case of porcine pandemic influenza A (H1N1) 2009 virus infection in October 2009. Human to pig transmission of virus was suspected. Unusual lung lesions were observed in fattening pigs, with red, lobular, multifocal to coalescing consolidation, most frequently in the cranial, middle, and accessory lobes. The main histopathological findings were epithelial degeneration and necrosis, lymphocyte infiltration in the epithelial lining and lamina propria of small bronchi and bronchioles, and peribronchial and peribronchiolar lymphocyte infiltrations. Infection with pandemic influenza A (H1N1) 2009 virus was confirmed by real-time RT-PCR and immunohistochemical detection of influenza A virus nucleoprotein in the lesions. This investigation shows that natural infection with the pandemic influenza A (H1N1) 2009 virus induces lung lesions similar to lesions described in experimental studies and natural infections with other swine-adapted subtypes of influenza A viruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447288 | PMC |
| http://dx.doi.org/10.1155/2011/565787 | DOI Listing |
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