AI Article Synopsis
- The prevalence of non-Rh-D isoimmunization in pregnancies ranges from 0.15% to 1.1%, with anti-Rh(c) alloimmunization occurring in about 0.07%.
- Late anemia is a common complication associated with isoimmunization, especially following procedures like intrauterine blood transfusions.
- Human recombinant erythropoietin has been identified as an effective treatment for preventing late anemia caused by both anti-Rh-D and non-anti-Rh-D isoimmunization.
Article Abstract
The overall prevalence of non-Rh-D isoimmunization seems to lie between 0.15% and 1.1%. Anti-Rh(c) alloimmunization, "little c," occurs in 0.07% of pregnancies and shows a quite broad clinical presentation. Late anemia is a frequent problem occurring in the setting of isoimmunization. It occurs more frequently after intrauterine blood transfusions or exsanguinotransfusion, and it can be thought as a hyporegenerative anemia. The authors describe the use of human recombinant erythropoietin in preventing late anemia in a case of anti-Rh(c) isoimmunization. The use of human recombinant erythropoietin is a valid tool for preventing late-onset anemia due to either anti-Rh-D or non-anti-Rh-D isoimmunization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MPH.0b013e318271f5b0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parvovirus B19 in Pregnancy-Do We Screen for Fifth Disease or Not?
Life (Basel)
December 2024
2nd Department of Obstetrics and Gynecology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Parvovirus B19 (B19V) infection is the cause of erythema infectiosum, or the "fifth disease", a widespread infection, potentially affecting 1-5% of pregnant women, in most cases without significant damage to the pregnancy or fetus. It follows a seasonal variation, with a higher prevalence in temperate climates, mainly in late winter and early spring. Women at increased risk include mothers of preschool and school-age children, and those working in nurseries, kindergartens, and schools.
View Article and Find Full Text PDFProlonged Severe CD4+ Lymphocytopenia and Hypogammaglobulinemia in Patients With Evans' Syndrome: A Case Report.
Cureus
December 2024
Department of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, JPN.
Primary immunodeficiency (PID) is one of the causes of secondary autoimmune hemolytic anemia (AIHA) and Evans' syndrome (ES). Serum immunoglobulins should be tested in patients with AIHA/ES, as common variable immunodeficiency is the most common PID of secondary AIHA/ES. However, it is not fully understood how immunodeficiency is assessed, in addition to serum immunoglobulins.
View Article and Find Full Text PDFPLK1 inhibition impairs erythroid differentiation.
Front Cell Dev Biol
December 2024
School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Polo-like kinase 1 (PLK1), a key regulator of the G2/M phase in mitosis, is frequently overexpressed in numerous tumors. Although PLK1 inhibitors have emerged as promising therapeutic agents for cancer, their use has been linked to significant anemia in a subset of patients, yet the underlying mechanisms remain poorly understood. In this study, we utilized an human umbilical cord blood-derived CD34 cell-based erythroid differentiation system, alongside a murine model, to investigate the impact of PLK1 inhibitors on erythropoiesis.
View Article and Find Full Text PDFFerric carboxymaltose for anemia in late pregnancy: a randomized controlled trial.
Nat Med
January 2025
Training and Research Unit of Excellence (TRUE), Blantyre, Malawi.
Over 46% of African pregnant women are anemic. Oral iron is recommended but often suboptimal, particularly late in pregnancy. Intravenous ferric carboxymaltose (FCM) could treat anemia in women in the third trimester in sub-Saharan Africa.
View Article and Find Full Text PDFAssessment of Cognitive Function Among Pregnant Women With Anemia in the Early and Late Trimester of Pregnancy.
Cureus
December 2024
Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, IND.
Article Synopsis
- The study investigates the cognitive function of anemic pregnant South Indian women by measuring reaction times (RT) in visual and auditory tasks during early and late pregnancy.
- Results indicated that women with anemia exhibited significantly longer reaction times compared to non-anemic women, with notable statistical differences in both visual and auditory assessments.
- The findings suggest a clear connection between anemia and impaired cognitive processing, highlighting the need for better management of anemia during pregnancy to support cognitive health.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!