Aim: To evaluate changes in prevalence of impaired motor coordination among 6-year-olds of a geographically defined area in Germany between the years 1990 and 2007.
Methods: Data from the obligatory school entrance examinations in the German state of North Rhine Westphalia between the years 1990 and 2007 were used. The number of children assessed per year varied from 81 517 to 124 086. The classification of impaired motor coordination was based on the combination of standardized screening and physicians' clinical impression of need of treatment. Logistic regression modelling was performed to evaluate the changes in prevalence of impaired motor coordination.
Results: Between 1990 and 2007, the prevalence of impaired motor coordination rose from 2.5% to 8.9% in boys and from 0.8% to 3.6% in girls. As the standard error of these percentages is below 0.15%, the changes are highly statistically significant.
Conclusion: The prevalence of impaired motor coordination tripled during the last decades in North Rhine Westphalia. This may imply that the prevalence of Developmental Coordination Disorder also increased. Factors that may explain the increasing prevalence include the increase in surviving preterm infants, increasing parental age at child birth, maternal and child obesity and decreasing child mobility.
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http://dx.doi.org/10.1111/apa.12057 | DOI Listing |
Sci Rep
January 2025
Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, Guizhou, China.
This study investigates the role of flavonoid Icaritin (ICT) in estrogen-deficient ovariectomized (OVX) female mice by activating the Estrogen receptor (ER)/ Phosphatidylinositol 3-kinase (PI3K)/Protein kinase B (Akt) signaling pathway, potentially delaying Parkinson's disease (PD) progression post-castration. Seventy-five 8-week-old C57BL/6J female mice underwent ovariectomy, followed by MPTP (20 mg/kg) injection for 7 days. ICT (20 mg/kg) was administered for 14 days, and motor function was assessed using various behavioral tests.
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January 2025
Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
The neuromuscular junction (NMJ) is essential for transmitting signals from motor neurons (MNs) to skeletal muscles (SKMs), and its dysfunction can lead to severe motor disorders. However, our understanding of the NMJ is limited by the absence of accurate human models. Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties.
View Article and Find Full Text PDFBrain Res
January 2025
epartment of Basic Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China. Electronic address:
Whisker deprivation at different stages of early development results in varied behavioral outcomes. However, there is a notable lack of systematic studies evaluating the specific effects of whisker deprivation from postnatal day 0 (P0) to P14 on adolescent behavioral performance in mice. To investigate these effects, C57BL/6J mice underwent whisker deprivation from P0 to P14 and were subsequently assessed at 5 weeks of age using a battery of tests: motor skills were evaluated using open field test; emotional behavior was evaluated using a series of anxiety- and depression-related behavioral tests; cognitive function was examined via novel location and object recognition tests; and social interactions were analyzed using three-chamber social interaction test.
View Article and Find Full Text PDFSLAS Technol
January 2025
Faculty of Medicine, Jingchu Institute of Technology, Jingmen 448000, Hubei, China. Electronic address:
Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia, and its symptoms include easy forgetting, distraction, and mental deterioration. This directly affects the patient's motor function, daily living ability, and social adaptability, and brings many difficulties to the patient's reintegration into society. Therefore, clinical research on MCI is very necessary.
View Article and Find Full Text PDFRes Dev Disabil
January 2025
Department of Developmental and Social Psychology, University of Padova, Italy.
Background: Neurodevelopmental conditions often exhibit overlapping symptoms, posing challenges for differential diagnosis. Developmental Coordination Disorder (DCD) manifests as fundamental motor impairments, often along with co-occurring visuospatial difficulties. Nonverbal Learning Disorder (NLD) features visuospatial core challenges, with a less consistent characterization of its motor profile.
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