Lipids peroxidative oxidation as well as antioxidative enzymes superoxidedismutase and catalase activity state at the mice sensibilization with ovalbumine, its correction with fulleren FC60 as well as by its forms (FC60-OVA, mFC60 mFC60-OVA) modified and conjugated with ovalbumines have been studied. It has been demonstrated that the mice sensibilization with ovalbumin leads to the tissues peroxidative lipid oxidation processes enforcement as well as lowering antioxidative enzymes activity in lungs and spleen. Used different rulleren forms expressed antioxidative effect and modifying effect to antioxidative protection enzymes at a given pathology. The influence of fulleren FC 60 and its modified form (1,2-methanofulleren-C60)61-carbolacid was the mostly effective. The data recieved testify to the prospects of the fullerens further investigation as the potential medicines.
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Semin Immunopathol
January 2025
Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
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Division of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, China.
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Department of Biochemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh, 11451, Saudi Arabia.
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