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Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration.
Bioact Mater
April 2025
Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, 210029, Nanjing, China.
Bone defect repair remains a great challenge in the field of orthopedics. Human body essential trace element such as copper is essential for bone regeneration, but how to use it in bone defects and the underlying its mechanisms of promoting bone formation need to be further explored. In this study, by doping copper into mesoporous bioactive glass nanoparticles (Cu-MBGNs), we unveil a previously unidentified role of copper in facilitating osteoblast mitophagy and mitochondrial dynamics, which enhance amorphous calcium phosphate (ACP) release and subsequent biomineralization, ultimately accelerating the process of bone regeneration.
View Article and Find Full Text PDFImproving Advanced Care Planning Discussions at an Internal Medicine Clinic.
Cureus
December 2024
Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
Objective: The project aimed to standardize advanced care planning (ACP) at an internal medicine clinic by initiating physician-patient communication regarding the patient's knowledge, understanding, and openness to pursuing advanced medical directives.
Methods: Data collection was conducted from February 1 to April 1, 2024, with the study concluding on April 24, 2024. ACP was facilitated through an initial standardized six-question pre-intervention survey in both English and Spanish.
Acid-assisted polysaccharides extracted from protect against Alzheimer's disease by regulating the microbiota-gut-brain axis.
Front Nutr
December 2024
Department of Traditional Chinese Medicine, Henan Agricultural University, Zhengzhou, China.
In this study, an acid-assisted extraction strategy was used to extract a novel polysaccharide (ACP) from after which this polysaccharide was purified and subjected to extensive characterization. ACP was determined to have an average molecular weight of 15,580 Da in structural characterization studies, and it was found to primarily consist of glucose, galactose, L-fucose, and fructose at an 82.14:12.
View Article and Find Full Text PDFFacile colorimetric detection of As(V) in Rice with immobilized acid phosphatase on hollow metal-organic frameworks hybrid with peroxidase-like activity.
Food Chem X
January 2025
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Quantitative analysis of As(V) in rice is of great significance for food safety and heavy metal pollution control. Here, a facile colorimetric method for As(V) detection was constructed by using immobilized acid phosphatase (ACP) in hollow metal-organic frameworks hybrid. Metalloporphyrin and gold nanoparticles modified hollow zeolite imidazole framework-8 [Au/HZIF-8@TCPP(Fe)], named AuHT, was chosen here as ACP immobilizing carrier with peroxidase-like activity.
View Article and Find Full Text PDFacp³U: A Conserved RNA Modification with Lessons Yet to Unfold.
Mol Cell Biol
January 2025
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
RNA modifications are highly conserved across all domains of life, suggesting an early emergence and a fundamental role in cellular processes. The modification 3-(3-amino-3-carboxypropyl)uridine (acp³U) is found in tRNAs of eukaryotes and prokaryotes, and in the 16S rRNA of archaea. In eukaryotic rRNA, a complex modification containing the acp group, macpΨ is present at the analogous position.
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