AI Article Synopsis
- ChaC1 is a proapoptic protein triggered by endoplasmic reticulum stress, and its exact function was previously unknown.
- Recent studies show that the ChaC protein family acts as γ-glutamyl cyclotransferases, specifically degrading glutathione without affecting other similar peptides.
- Overexpressing these proteins results in glutathione depletion and increased cell death in yeast, highlighting a new cytosolic pathway for glutathione degradation that is conserved across all living organisms.
Article Abstract
ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo studies and novel in vitro assays that the ChaC family of proteins function as γ-glutamyl cyclotransferases acting specifically to degrade glutathione but not other γ-glutamyl peptides. The overexpression of these proteins (but not the catalytically dead E>Q mutants) led to glutathione depletion and enhanced apoptosis in yeast. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512401 | PMC |
| http://dx.doi.org/10.1038/embor.2012.156 | DOI Listing |
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