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Macroscopic placental changes associated with fetal and maternal events in diabetes mellitus. | LitMetric

AI Article Synopsis

  • The study aimed to examine placental changes in pregnant women with and without diabetes and how these changes affect their newborns.
  • Out of 124 women studied, 62 had diabetes (mostly gestational), and abnormalities were found in 79% of maternal and 95.2% of fetal placental surfaces, indicating significant issues like calcification and hematoma.
  • Results showed a correlation between newborn gender and placental changes, with women having gestational diabetes displaying more calcium deposits on their placentas compared to those with type I and type II diabetes.

Article Abstract

Objectives: The current study sought to identify macroscopic placental changes associated with clinical conditions in women with or without diabetes and their newborns.

Methods: The study population consisted of 62 pregnant women clinically diagnosed with diabetes and 62 healthy women (control group).

Results: Among the subjects with diabetes, 43 women (69.3%) were diagnosed with gestational diabetes mellitus, 15 had diabetes mellitus I (24.2%), and four had diabetes mellitus II (6.5%). The mean age of the women studied was 28.5 ± 5.71 years, and the mean gestational age of the diabetic women was 38.51 weeks. Of the 62 placentas from diabetic pregnancies, 49 (79%) maternal surfaces and 59 (95.2%) fetal surfaces showed abnormalities, including calcium and fibrin deposits, placental infarction, hematoma, and fibrosis. A statistical association was found between newborn gender and fetal and maternal placental changes (p = 0.002). The mean weight of the newborns studied was 3,287 ± 563 g for women with diabetes mellitus, 3,205 ± 544 g for those with gestational diabetes mellitus, 3,563 ± 696 g for those with diabetes mellitus II, and 3,095 ± 451 g for those with diabetes mellitus I.

Conclusions: Infarction, hematoma, calcification, and fibrin were found on the maternal and fetal placental surfaces in women with diabetes. Women with gestational diabetes and post-term infants had more calcium deposits on the maternal placental surface as compared to those with type I and type II diabetes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460024PMC
http://dx.doi.org/10.6061/clinics/2012(10)13DOI Listing

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