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Actinic keratosis with severe dysplasia and Bowen disease represent distinct pathways of intraepidermal squamous neoplasia: an immunohistochemical study.
Pathology
December 2024
Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, WA, Australia; School of Medicine, Notre Dame University, Fremantle, WA, Australia. Electronic address:
Intraepidermal squamous neoplasia is a precursor to invasive cutaneous squamous cell carcinoma. The most common type of intraepidermal squamous neoplasia is actinic keratosis (AK), although there is compelling clinicopathological evidence of a second distinct pattern of squamous dysplasia termed Bowen disease (BD). The distinction between these pathways of dysplasia has been inconsistently delineated in the literature.
View Article and Find Full Text PDFPhenotypic and genotypic analysis of SERPINA12-related autosomal recessive palmoplantar keratoderma in southwestern China.
J Dermatol
December 2024
Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Hereditary palmoplantar keratoderma (hPPK) comprises a clinical and heterogeneous group of skin disorders characterized by hyperkeratosis of the palms and soles. Variants of SERPINA12 have been implicated in autosomal recessive diffuse hPPK, which shares similarities with Nagashima-type PPK due to biallelic variants in SERPINB7. To date, seven SERPINA12 variants have been found in 11 patients with biallelic SERPINA12 variants worldwide.
View Article and Find Full Text PDFCharacteristics and diagnostic performance of nonechoplanar diffusion-weighted imaging in detecting canine tympanokeratoma (cholesteatoma).
Vet Radiol Ultrasound
November 2024
Department of Diagnostic Imaging, Oniris National Veterinary School, Centre Hospitalier Universitaire Vétérinaire, Nantes, France.
Article Synopsis
- Tympanokeratomas (cholesteatomas) are harmful growths in the middle ear and are often surgically treated; this study focuses on using non-EP diffusion-weighted MRI for diagnosis in dogs.
- The research involved analyzing 62 dog ears diagnosed with either tympanokeratomas or other types of otitis media, with non-EP DWI achieving a detection accuracy of 77.4% and ADC values ranging between 517 to 2447 mm/s.
- A specific ADC cut-off value of 916 mm/s was found to effectively indicate tympanokeratomas, providing a combined 80.9% accuracy when considering both qualitative DWI images and ADC maps.
Pigmented basal cell carcinoma mimicking nodular melanoma.
BMJ Case Rep
September 2024
Department of Pathology, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.
Article Synopsis
- Basal cell carcinoma (BCC) is the most common type of primary skin cancer, with pigmented BCC being a rare variant that can resemble nodular melanoma (NM).
- A case is presented involving a 40-something woman with a hyperpigmented nodule on her cheek that looked like pigmented NM, but dermoscopy revealed distinct features.
- After initial biopsy showed signs of trichoepithelioma, complete excision confirmed it was pigmented BCC; awareness of this rare presentation is essential for proper diagnosis and management, especially in dark-skinned patients.
Pityriasis Rubra Pilaris in an Atopic Dermatitis Patient: A Case Report.
Cureus
August 2024
Dermatology, King Abdulaziz Hospital, Makkah, SAU.
Article Synopsis
- - Pityriasis rubra pilaris (PRP) is a rare skin condition characterized by chronic inflammation and scaly patches, affecting mostly the extremities while sparing the trunk.
- - A 43-year-old woman with a history of atopic dermatitis presented with itchy skin lesions, and after thorough examination and biopsy, she was diagnosed with atypical adult PRP (type II).
- - The patient was treated with narrowband UVB phototherapy, leading to complete clearance of skin lesions within two months, and she has remained lesion-free for two years during follow-up.
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