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Pseudoephedrine and false-positive immunoassay urine drug tests for amphetamine.
Pharmacotherapy
May 2013
Aegis Sciences Corporation, 365 Great Circle Road, Nashville, TN 37228, USA.
Adolescent abuse of dextromethorphan.
Clin Pediatr (Phila)
September 2005
Department of Pediatrics, Inova Fairfax Hospital for Children, Falls Church, Virginia 22180, USA.
Dextromethorphan hydrobromide (DXM), a constituent of more than 125 patent cough/cold remedies, is the most popular antitussive medication in the United States. Cough syrups or capsules also contain additional ingredients such as acetaminophen, chlorpheniramine maleate, guaifenesin, and/or pseudoephedrine, and toxicity with overdosage is additive to that of dextromethorphan alone. An unknown number of adolescents in the United States and Europe intoxicate themselves with acute megadoses of dextromethorphan.
View Article and Find Full Text PDFEvaluation of ephedrine, pseudoephedrine and phenylpropanolamine concentrations in human urine samples and a comparison of the specificity of DRI amphetamines and Abuscreen online (KIMS) amphetamines screening immunoassays.
J Forensic Sci
January 2004
Aegis Sciences Corporation, 345 Hill Ave, Nashville, TN 37210, USA.
The purpose of this study was to evaluate the ability of two amphetamine class screening reagents to exclude ephedrine (EPH), pseudoephedrine (PSEPH), and phenylpropanolamine (PPA) from falsely producing positive immunoassay screening results. The study also sought to characterize the prevalence and concentration distributions of EPH, PSEPH, and PPA in samples that produced positive amphetamine screening results. Approximately 27,400 randomly collected human urine samples from Navy and Marine Corps members were simultaneously screened for amphetamines using the DRI and Abuscreen online immunoassays at a cutoff concentration of 500 ng/mL.
View Article and Find Full Text PDF[Skin tests in the study of drug eruptions with suspected immuno-allergic mechanism].
Bull Acad Natl Med
October 2000
Service de Dermatologie, Hôpital Fournier, Nancy.
Skin testing (patch tests, prick test and intradermal tests) with the suspected compound has been reported to be helpful in determining the cause of cutaneous adverse drug reactions (ADRs), but the value and specificity of these tests need to be determined. In a previously published study involving 72 patients, we observed positive results in 72% of the cases, in 43%, 24% and 67% in patch, prick and intradermal skin tests, respectively. The results of skin tests varied with the clinical type of cutaneous ADR, as a significantly higher number of positive patch tests was observed in maculopapular rashes (59%) than in urticarial reactions (13%) or in eythrodermic ADR (80%).
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