The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479305 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2012.09.022 | DOI Listing |
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