AI Article Synopsis
- * Results showed that LMHFV treatment significantly increased blood flow and vascular volume at the fracture site, particularly noticeable at 2 and 4 weeks post-treatment, with OVX (osteoporotic) rats experiencing some improvements despite being less effective than the Sham (normal) group.
- * Overall, while osteoporotic fractures had less robust blood vessel formation, LMHFV treatment demonstrated its potential to enhance both blood flow and angiogenesis, promoting better healing outcomes in fractures compared to controls.
Article Abstract
This study aimed to investigate the mechanism of low-magnitude high-frequency vibration (LMHFV) treatment on angiogenesis and blood flow for enhancement of fracture healing. Nine-month-old ovariectomized (OVX) and sham-operated (Sham) rats received closed fractures creation at the femora and were randomized into LMHFV treatment (Sham-V, OVX-V) or control (Sham-C, OVX-C) groups. Pulsed-wave Doppler indicated an increase in blood flow velocity of the femoral artery at weeks 2 (OVX pair: p = 0.030) and 4 (OVX pair: p = 0.012; Sham pair: p = 0.020) post-treatment. Significantly enhanced vascular volume (VV) at the fracture site in the vibration groups was demonstrated by 3-D high-frequency power Doppler at week 2 (Sham pair: p = 0.021) and micro-computed tomography (microCT) microangiography at weeks 2 (OVX pair: p = 0.009) and 4 (OVX pair: p = 0.034), which echoed the osteogenesis findings by radiographic and microCT analysis. VV in the OVX groups was inferior to the Sham groups. However, OVX-V showed higher percentages of angiogenic enhancement than Sham-V. Despite impaired neo-angiogenesis in osteoporotic fractures, LMHFV could increase blood flow and angiogenesis in both normal and osteoporotic fractures, thus enhancing fracture healing.
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| http://dx.doi.org/10.1016/j.ultrasmedbio.2012.07.025 | DOI Listing |
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