Self-assembling properties of all γ-cyclic peptides containing sugar amino acid residues.

Org Biomol Chem

Departamento de Química Orgánica, Centro Singular de Investigación en Química Biológica y Materiales Moleculares y Unidad Asociada al CSIC, Campus Vida, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Published: November 2012

In this study, a novel dimer-forming cyclic peptide composed exclusively by cyclic γ-amino acids with a saccharide-like outer surface is described. The antiparallel β-sheet type hydrogen bonding interactions responsible for the large association constant in non-polar solvents constitute a suitable model for a novel class of self-assembling peptide nanotubes.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2ob26612aDOI Listing

Publication Analysis

Top Keywords

self-assembling properties
4
properties γ-cyclic
4
γ-cyclic peptides
4
peptides sugar
4
sugar amino
4
amino acid
4
acid residues
4
residues study
4
study novel
4
novel dimer-forming
4

Similar Publications

Gaseous Synergistic Self-Assembly and Arraying to Develop Bio-Organic Photocapacitors for Neural Photostimulation.

Adv Sci (Weinh)

January 2025

State Key Laboratory of Fluid Power and Mechatronic Systems, Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310058, China.

Bioinspired supramolecular architectonics is attracting increasing interest due to their flexible organization and multifunctionality. However, state-of-the-art bioinspired architectonics generally take place in solvent-based circumstance, thus leading to achieving precise control over the self-assembly remains challenging. Moreover, the intrinsic difficulty of ordering the bio-organic self-assemblies into stable large-scale arrays in the liquid environment for engineering devices severely restricts their extensive applications.

View Article and Find Full Text PDF

This study introduces a method for synthesizing electrically conductive hydrogels by incorporating a self-assembled, percolating graphene network. Our approach differs from previous approaches in two crucial aspects: using pristine graphene rather than graphene oxide and self-assembling the percolation network rather than creating random networks by blending. We use pristine graphene at an oil-water interface to stabilize a water-in-oil emulsion, successfully creating hydrogel foams with conductivities up to 15 mS m and tunable porosity.

View Article and Find Full Text PDF

Host-directed therapies (HDTs) resolve excessive inflammation during tuberculosis (TB) disease, which leads to irreversible lung tissue damage. The peptide-based nanostructures possess intrinsic anti-inflammatory and antioxidant properties among HDTs. Native carnosine, a natural dipeptide with superior self-organization and functionalities, was chosen for nanoformulation.

View Article and Find Full Text PDF

Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis.

Beilstein J Org Chem

January 2025

Institute of Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

Polysarcosine emerges as a promising alternative to polyethylene glycol (PEG) in biomedical applications, boasting advantages in biocompatibility and degradability. While the self-assembly behavior of block copolymers containing polysarcosine-containing polymers has been reported, their potential for shape transformation remains largely untapped, limiting their versatility across various applications. In this study, we present a comprehensive methodology for synthesizing, self-assembling, and transforming polysarcosine-poly(benzyl glutamate) block copolymers, resulting in the formation of bowl-shaped vesicles, disks, and stomatocytes.

View Article and Find Full Text PDF

Chiral alkynyl Au(I) complexes: Enhancing chiroptical amplification of circularly polarized luminescence through supramolecular helices.

Spectrochim Acta A Mol Biomol Spectrosc

January 2025

State Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, PR China. Electronic address:

The construction of helical structures through self-assembly and the exploration of their formation mechanisms not only amplify chiroptical properties but also provide profound insights into the structures and functions of natural helices. In this study, we developed a chiral Au(I) system based on BINAP and alkynyl ligands. The modification of the length or number of alkyl chains at the terminal positions of the alkynyl ligands significantly impacted the self-assembly behavior of the complexes.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!