AI Article Synopsis
- * Reversine has advantages over traditional methods like somatic cell nuclear transfer or gene transfection, but its exact mechanism is not well understood.
- * The findings suggest that using reversine might be a better chemical approach for creating induced pluripotent stem cells in the future.
Article Abstract
Objective: To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine.
Methods: The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed.
Results: To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear.
Conclusion: The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.
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