Pachyonychia congenita-associated alopecia.

Case Rep Pathol

Department of Dermatopathology, Tehran University of Medical Sciences, Tehran, Iran.

Published: October 2012

A 5-year-old female, known case of pachyonychia congenita, presented with diffuse hair loss; remaining hairs were easily plucked kinky hairs. Hair samples from patient were investigated using a light microscope. The hairs of the patients were mainly anagen hairs and unlike normal plucked anagen hairs, showed keratinization and cornification of their hair bulbs. No specific hair shaft abnormality was found.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465886PMC
http://dx.doi.org/10.1155/2012/850658DOI Listing

Publication Analysis

Top Keywords

anagen hairs
8
hairs
5
pachyonychia congenita-associated
4
congenita-associated alopecia
4
alopecia 5-year-old
4
5-year-old female
4
female case
4
case pachyonychia
4
pachyonychia congenita
4
congenita presented
4

Similar Publications

Background: Rex rabbit is famous for its silky and soft fur coat, a characteristic predominantly attributed to its hair follicles. Numerous studies have confirmed the crucial roles of mRNAs and non-coding RNAs (ncRNAs) in regulating key cellular processes such as cell proliferation, differentiation, apoptosis and immunity. However, their involvement in the regulation of the hair cycle in Rex rabbits remains unknown.

View Article and Find Full Text PDF

Moracin M promotes hair regeneration through activation of the WNT/β-catenin pathway and angiogenesis.

Arch Dermatol Res

January 2025

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 54538, South Korea.

Hair follicle growth depends on the intricate interaction of cells within the follicle and its vascular supply. Current FDA-approved treatments like minoxidil have limitations, including side effects and the need for continuous use. Moracin M, a compound from Moraceae family, was investigated for its effects on hair growth and vascular regeneration.

View Article and Find Full Text PDF

Background: Trichoscopy is a simple, noninvasive tool to help in the diagnosis of various hair and scalp disorders. There is paucity of data on the normal trichoscopic parameters of hair density and diameter in the Indian population.

Aim: The aim of this study was to establish the trichoscopic patterns of hair and scalp in healthy Indian males and to provide a framework for future reference.

View Article and Find Full Text PDF

Evolution of long scalp hair in humans.

Br J Dermatol

January 2025

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.

The ability to grow long scalp hair is a distinct human characteristic. It probably originally evolved to aid in cooling the sun-exposed head, although the genetic determinants of long hair are largely unknown. Despite ancestral variations in hair growth, long scalp hair is common to all extant human populations, which suggests its emergence before or concurrently with the emergence of anatomically modern humans (AMHs), approximately 300 000 years ago.

View Article and Find Full Text PDF

MeRIP-seq data analysis and validation reveal the regulatory role of mA modified circRNAs in the apoptosis of secondary hair follicle cells in Inner Mongolia cashmere goats.

Comp Biochem Physiol Part D Genomics Proteomics

January 2025

College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010010, China; Inner Mongolia Autonomous Region Key Laboratory of Biomanufacturing, Hohhot 010010, China. Electronic address:

As a widely epigenetic modification, mA (N-methyladenosine, mA) can regulate the degradation, translation, and other biological functions of circRNAs through dynamic reversible processes. It plays an important role in regulating the life activities of biological organisms, particularly in cell differentiation, apoptosis, embryonic development, stress response, and innate immunity. In this study, bioinformatics analysis, qRT-PCR identification, FISH subcellular localization, and ceRNA network construction were performed on mA modified circRNAs regulating the apoptosis of secondary hair follicle cells of Inner Mongolia Albas white cashmere goats based on the skin mA sequencing data of secondary hair follicles in anagen and catagen.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!