In this study 13- to 14-day fetal thymic lobes were implanted within the anterior eye chambers in mice either with or without a syngeneic newborn sympathetic ganglion. It was observed after 6 weeks of implantation that the thymic lobes that grew with the ganglia had fewer lymphoid cells than their counterparts which were grown without the ganglia. The cells that developed within the thymic lobes were Thy-1- and peanut agglutinin-positive. The thymic lobes that grew with sympathetic ganglia also showed the presence of adrenergic nerves, perhaps due to reinnervation of the thymic grafts from the ganglia.
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http://dx.doi.org/10.1159/000146858 | DOI Listing |
Front Transplant
November 2024
Columbia Center of Translational Immunology, Columbia University, New York, NY, United States.
Background: Despite advances in immunosuppressive therapies, chronic rejection and immunosuppression-related complications remain significant challenges in transplantation. Developing transplantation tolerance through thymus transplantation may offer a solution. This paper details our technique for procuring and transplanting porcine vascularized thymic lobes (VTL), which can be utilized to study and research allogeneic and xenogeneic transplantation models in large animals.
View Article and Find Full Text PDFFront Transplant
November 2024
Columbia Center for Transplantation Immunology, Columbia University, New York, NY, United States.
Introduction: Thymokidneys (TK) have been constructed to transplant life-supporting kidney grafts containing donor thymic tissue to induce transplant tolerance. Historically, TKs were constructed by inserting pieces of thymus tissue under the kidney capsule using an intra-abdominal or posterior retroperitoneal (lateral/flank) approach. The intra-abdominal approach is technically easier but causes intra-abdominal adhesions and makes kidney procurement more challenging.
View Article and Find Full Text PDFPLoS One
August 2024
Quantitative and Systems Biology Graduate Program, University of California Merced, Merced, California, United States of America.
The thymus, a key organ in the adaptive immune system, is sensitive to a variety of insults including cytotoxic preconditioning, which leads to atrophy, compression of the blood vascular system, and alterations in hemodynamics. Although the thymus has innate regenerative capabilities, the production of T cells relies on the trafficking of lymphoid progenitors from the bone marrow through the altered thymic blood vascular system. Our understanding of thymic blood vascular hemodynamics is limited due to technical challenges associated with accessing the native thymus in live mice.
View Article and Find Full Text PDFSci Adv
January 2024
Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Ultrasound
August 2023
Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Ultrasound evaluation of normal, ectopic, asymmetric, and hyperplastic thymus and also its differentiation from abnormalities are challenging in children, and few studies have addressed this issue. This study aimed to investigate the thymus sonographic changes with age.
Methods: In this cross-sectional study, 118 healthy children were categorised into six age groups.
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