Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality. There is no effective treatment or prevention till date for HCV infection. We describe the computed binding of 10 compounds to the allosteric binding site of RNA dependent RNA polymerase enzyme. These compounds were identified from the ZINC database through virtual screening followed by ADMET evaluation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449378 | PMC |
| http://dx.doi.org/10.6026/97320630008716 | DOI Listing |
Publication Analysis
Top Keywords
virtual screening
8
rna dependent
8
dependent rna
8
rna polymerase
8
hcv infection
8
structure based
4
based virtual
4
screening inhibitors
4
inhibitors binding
4
binding allosteric
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!