AI Article Synopsis
- Autism spectrum disorders (ASD) can be linked to various causes, including structural brain issues like agenesis of the corpus callosum (AgCC).
- A study of 106 individuals with AgCC found significant autism traits, showing that 45% of children, 35% of adolescents, and 18% of adults had scores above the autism-screening threshold.
- There is a notable relationship between imagination skills and brain connectivity in individuals with AgCC, suggesting that those with this condition should be specifically evaluated for ASD during diagnosis.
Article Abstract
Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625480 | PMC |
| http://dx.doi.org/10.1007/s10803-012-1653-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!