Molecular modeling and the art of computer-aided drug discovery seldom make much use of statistics, despite being fields that can not calculate important properties with great reliability. The 2013 CADD Gordon conference intends to examine what prevents a more effective use of statistics in routine modeling and to raise consciousness as to what is possible. Practical methods will be discussed, deeper issues in applying standard approaches addressed and research on successes and failures in other disciplines presented by invited experts.
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http://dx.doi.org/10.1007/s10822-012-9613-7 | DOI Listing |
Ther Clin Risk Manag
January 2025
Department of Otolaryngology Head & Neck Surgery, Monash Health, Melbourne, Australia.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is often severe, debilitating and difficult to treat. Recent randomised control trials (RCTs) of biologics that target key inflammatory pathways have demonstrated clinical efficacy in treating CRSwNP. Such RCTs must facilitate meta-analysis.
View Article and Find Full Text PDFChina CDC Wkly
December 2024
Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an City, Shaanxi Province, China.
China faces a critical public health challenge with obesity rates exceeding 50% among adults and 20% among children. In response, the National Health Commission launched a comprehensive three-year "Year of Weight Management" initiative in March 2024, further emphasized by the 36th Patriotic Health Month's theme "Healthy Towns - Healthy Weight" in April 2024. These initiatives underscore the urgent necessity for implementing comprehensive strategies to combat obesity and its associated non-communicable diseases.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Liaoning Key Laboratory for Chemical Clean Production, Liaoning Key Laboratory for Surface Functionalization of Titanium Dioxide Powder, Institute of Ocean Research, Institute Environmental Research, College of Chemistry and Material Engineering, Bohai University, Jinzhou 121013 Liaoning, China. Electronic address:
Developing new conductive primers to ensure electrostatic spraying is crucial in response to the call for lightweight production of new energy vehicles. We report a stabilized material, Fe-T/G, of Fe-doped TiO composite graphene synthesized by a simple hydrothermal and electrostatic self-assembly method. The resistivity decreases from 0.
View Article and Find Full Text PDFBraz J Psychiatry
January 2025
Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil. Laboratório Interdisciplinar de Neurociências Integrativas (LiNC), Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia (PROESQ), Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP, São Paulo, SP, Brazil.
Objective: This article aims to systematically review the studies on schizophrenia in Brazil, addressing geographical coverage as an indicator of sampling representativeness, essential to infer results' generalization. It also highlights the variation in research funding across different regions.
Methods: We searched for studies carried out until July 2023.
J Clin Neurosci
January 2025
Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic. Electronic address:
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