AI Article Synopsis
- The study examined how continuous flow LVAD pumps affect platelet aggregation in calves using a MagLev centrifugal blood pump.
- The researchers measured platelet aggregation before, during, and after surgery while administering anticoagulants like heparin and warfarin, alongside aspirin for antiplatelet therapy.
- Results showed that successful pump operation caused a decrease in platelet aggregation, suggesting that how platelets react initially to the pump may influence long-term outcomes of mechanical heart support.
Article Abstract
The impact of continuous flow left ventricular assist device (LVAD) pumping on platelet aggregation was investigated in animal experiments utilizing six calves. A single-use MagLev centrifugal blood pump, MedTech MagLev, was used to bypass the calves' hearts from the left atrium to the descending aorta at a flow rate of 50 ml/kg/min. The LVAD's impact on blood coagulation activities was evaluated based on the platelet aggregability, which was measured with a turbidimetric assay method during the preoperative, operative, and postoperative periods. Heparin and warfarin were used for anticoagulation, while aspirin was used for the antiplatelet therapy. A decrease in platelet aggregation immediately after the pump started was observed in the cases of successful long-term pump operation, while the absence of such a decrease might have caused coagulation-related complications to terminate the experiments. Thus, the platelet aggregability was found to be significantly affected by the pump, and its initial trend may be related to the long-term outcome of the mechanical circulatory support.
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| http://dx.doi.org/10.1007/s10047-012-0664-2 | DOI Listing |
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