Objectives: The aim of this study was to examine age differences in high- and low-arousal positive and negative affect, and associations of physical functioning with affect over the latter half of the life course.
Method: Participants consisted of 39,958 midlife and older adults contributing to DYNOPTA; a large-scale collaborative project concerned with pooling data from Australian studies of aging. Items assessing the experience of discrete emotions were selected to represent different combinations of high- and low-arousal affect, and positive and negative valence affect.
Results: Older adults were more likely to endorse low-arousal positive affect, and less likely to endorse negative affect (both high and low arousal) relative to those in midlife. Better self-reported physical functioning was associated with younger age, higher positive, and lower negative affect, with physical functioning emerging as a suppressor of associations of age with affect in regression analyses.
Conclusions: The results, based on a very large sample of older adults, are consistent with those of other studies demonstrating lower levels of negative emotion among older, relative to midlife adults. The findings also highlight the relevance of physical functioning to emotional well-being over the latter part of the life course.
Background: The increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), parallels the rise in sedentary lifestyles. MASLD is the most common form of steatotic liver disease (SLD), which represents the umbrella beneath which the vast majority of chronic liver diseases fall, including alcohol-related liver disease and their overlap. These conditions are the leading contributors to chronic liver disease, significantly impacting global morbidity and mortality.
Diffusion-weighted imaging (DWI) has been frequently used to examine age-related deterioration of white matter microstructure and its relationship to cognitive decline. However, typical tensor-based analytical approaches are often difficult to interpret due to the challenge of decomposing and (mis)interpreting the impact of crossing fibers within a voxel. We hypothesized that a novel analytical approach capable of resolving fiber-specific changes within each voxel (i.
It is now understood that brain metastases do not occur randomly but have distinct spatial patterns depending on the origin of the cancer. According to the "seed and soil" hypothesis, the final colonization of metastatic cells is the result of their adaptation to the altered environment. To investigate the most favorable microenvironment for brain metastasis, we analyzed neuroimaging data from 177 patients with breast cancer brain metastasis and 548 patients with lung cancer brain metastasis to create a replicable probabilistic map of metastatic locations.
Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults.
Not harming others is widely regarded as a fundamental tenet of human morality. Harm aversion based on the consequences of an action is called utilitarianism while focusing on the action itself is associated with deontology. This study investigated how interoceptive processing affects the neural processing of utilitarian and deontological moral decision-making.
