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Nutrients
November 2024
2nd Department of Obstetrics and Gynecology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
: The rapidly increasing rate of obesity has become an extremely important public health problem, particularly in developed countries. Obesity is associated with a range of health problems, often referred to as the metabolic syndrome. Adipose tissue is now regarded as an endocrine organ responsible for the hormonal secretion of adipokines, which are cytokines involved in various physiological processes.
View Article and Find Full Text PDFBiological production of nicotinamide mononucleotide: a review.
Crit Rev Biotechnol
December 2024
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Nicotinamide mononucleotide (NMN) presents significant therapeutic potential against aging-related conditions, such as Alzheimer's disease, due to its consistent and strong pharmacological effects. Aside from its anti-aging effect, NMN is also an emerging noncanonical cofactor for orthogonal metabolic pathways in the field of biomanufacturing. This has significant advantages in the field of metabolic engineering, allowing cells to produce unnatural chemicals without disrupting the natural cellular processes.
View Article and Find Full Text PDFNAD+ METABOLISM RESTRICTION BOOSTS HIGH-DOSE MELPHALAN EFFICACY IN PATIENTS WITH MULTIPLE MYELOMA.
Blood Adv
December 2024
IRCCS San Martino, Italy.
Elevated levels of the nicotinamide adenine dinucleotide (NAD+)-generating enzyme nicotinamide phosphoribosyltransferase (NAMPT) are a common feature across numerous cancer types. Accordingly, we previously reported pervasive NAD+ dysregulation in Multiple Myeloma (MM) cells in association with upregulated NAMPT expression. Unfortunately, albeit being effective in preclinical models of cancer, NAMPT inhibition has proven ineffective in clinical trials due to the existence of alternative NAD+ production routes utilizing NAD+ precursors other than nicotinamide.
View Article and Find Full Text PDFHigh-Level Production of Nicotinamide Mononucleotide by Engineered .
J Agric Food Chem
December 2024
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Nicotinamide mononucleotide (NMN), a key precursor of NAD, is a promising nutraceutical due to its excellent efficacy in alleviating aging and disease. The bioproduction of NMN faces challenges related to incomplete metabolic engineering and insufficient metabolic flux. Here, we constructed an NMN synthesis pathway in BW25113 by deleting the competitive pathway genes and introducing three heterologous genes encoding the key enzymes nicotinamide phosphoribosyltransferase (NAMPT), phosphoribosyl pyrophosphate synthetase and an NMN transporter.
View Article and Find Full Text PDFExtracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis.
Genes Genomics
December 2024
School of Bioscience and Technology, Chengdu Medical College, Chengdu, China.
Article Synopsis
- Metastasis poses a significant challenge in treating colorectal cancer (CRC), with cancer-associated fibroblasts (CAFs) playing a crucial role in this process.
- The study investigates the effects of visfatin, an extracellular protein, on CAFs and how it influences CRC metastasis through mechanisms involving inflammatory factors and the JAK-STAT signaling pathway.
- Results show that visfatin enhances the invasive and migratory abilities of CRC cells by activating inflammatory responses in CAFs, suggesting that targeting this interaction could be a potential therapeutic strategy for CRC.
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