The symptoms of bipolar disorder affect and are affected by the functioning of family environments. Little is known, however, about the stability of family functioning among youth with bipolar disorder as they cycle in and out of mood episodes. This study examined family functioning and its relationship to symptoms of adolescent bipolar disorder, using longitudinal measures of family cohesion, adaptability, and conflict. Parent- and adolescent-reported symptom and family functioning data were collected from 58 families of adolescents with bipolar disorder (mean age =14.48±1.60; 33 female, 25 male) who participated in a 2-year randomized trial of family-focused treatment for adolescents (FFT-A). Cohesion and adaptability scores did not significantly change over the course of the study. Parent-reported conflict prior to psychosocial treatment moderated the treatment responses of families, such that high-conflict families participating in FFT-A demonstrated greater reductions in conflict over time than low-conflict families. Moreover, adolescent mania symptoms improved more rapidly in low-conflict than in high-conflict families. For all respondents, cohesion, adaptability, and conflict were longitudinally correlated with adolescents' depression scores. Finally, decreases in parent-reported conflict also predicted decreases in adolescents' manic symptoms over the 2-year study. Findings suggest that family cohesion, adaptability, and conflict may be useful predictors of the course of adolescent mood symptoms. Family conflict may be an important target for family intervention in early onset bipolar disorder.
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http://dx.doi.org/10.1016/j.beth.2012.04.005 | DOI Listing |
Children (Basel)
December 2024
Lenval University Children's Hospital, SUPEA (University Department of Child and Adolescent Psychiatry), Competence Center for Rare Diseases with Psychiatric Expression (CC MREP), Expert Center for Pediatric Psychotrauma (CE2P), 06200 Nice, France.
Background: The first year of life is the period of greatest brain plasticity. Postpartum depression can adversely affect the first interactions with the child and, consequently, their emotional, social, and cognitive development.
Objectives: First, to describe the developmental profile of six-month-old infants of mothers suffering from severe postpartum depression, and, second, to compare the development of infants whose mothers suffer from depression with or without bipolar disorder.
Healthcare (Basel)
January 2025
Research, Development, and Innovation Laboratory, Mundiapolis University, Casablanca 20180, Morocco.
Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that starts in childhood, sometimes persisting into adulthood. It puts a strain on their social, professional, family, and environmental lives, which can exacerbate disorders such as anxiety, depression, and bipolar disorder. : This paper aims to predict ADHD in children and adults and explain the main factors impacting this disorder.
View Article and Find Full Text PDFAm J Geriatr Psychiatry
January 2025
University Hospitals Cleveland Medical Center (MS), Cleveland, OH; Case Western Reserve University School of Medicine (MS), Cleveland, OH.
Objectives: To evaluate cariprazine in adults with older- and younger-age bipolar I disorder (OABD-I and YABD-I) and compare treatment effects between them.
Design And Setting: Pooled post-hoc analysis of studies in depressive or acute manic/mixed episodes associated with bipolar I disorder.
Participants: 475/1383 patients (34.
J Affect Disord
January 2025
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China. Electronic address:
Background: ClockΔ19 mice demonstrate behavioral characteristics and neurobiological changes that closely resemble those observed in bipolar disorder (BD). Notably, abnormalities in the hippocampus have been observed in patients with BD, yet direct molecular investigation of human hippocampal tissue remains challenging due to its limited accessibility.
Methods: To model BD, ClockΔ19 mice were employed.
Schizophr Bull
January 2025
Psychology, Michigan State University, East Lansing, MI, 48824, United States.
Background And Hypothesis: Sequential saccade planning requires corollary discharge (CD) signals that provide information about the planned landing location of an eye movement. These CD signals may be altered among individuals with schizophrenia (SZ), providing a potential mechanism to explain passivity and anomalous self-experiences broadly. In healthy controls (HC), a key oculomotor CD network transmits CD signals from the thalamus to the frontal eye fields (FEF) and the intraparietal sulcus (IPS) and also remaps signals from FEF to IPS.
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