AI Article Synopsis
- Vascular inflammation is key in atherosclerosis development, influencing everything from initial lipid streaks to plaque rupture that leads to cardiovascular issues.
- C-reactive protein (CRP), particularly when measured using high-sensitivity methods (hs-CRP), is the most researched inflammatory biomarker in this context.
- The article reviews the relationship between hs-CRP and cardiovascular risk, ultimately assessing its clinical significance in risk evaluation.
Article Abstract
Vascular inflammation plays a crucial role in the pathogenesis of atherosclerosis and mediates various stages of atherosclerotic plaque development, from lipid streak formation to the plaque rupture and destabilization that precedes the clinical syndromes of cardiovascular disease. Inflammatory biomarkers constitute valuable tools to study this process, enabling the effects of different therapeutic interventions to be assessed. Currently, C-reactive protein (CRP) determined by high-sensitivity methods (hs-CRP) is the most extensively studied biomarker. Data regarding hs-CRP and cardiovascular risk, though largely consistent, are of unclear clinical relevance. This article provides a comprehensive review of current knowledge concerning cardiovascular risk and hs-CRP, and concludes with an evidence-based analysis of the current role of hs-CRP in cardiovascular risk assessment.
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| http://dx.doi.org/10.1016/j.repc.2012.02.018 | DOI Listing |
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