Background: This study investigated the association among breastfeeding, serum zinc levels, and nutritional status of children.
Subjects And Methods: One hundred healthy infants were included in the study. Anthropometric measurements of the children were taken, and their plasma zinc levels were determined. The mothers were interviewed about the duration of breastfeeding and nutrition pattern of the children at the time of zinc measurement.
Results: Low zinc levels were associated with lower weight measurements (r=0.49, p<0.001), but the association between height and zinc level was not statistically significant (r=0.18, p>0.05). There was a negative correlation between breastfeeding duration and weight-for-age percentile (r=-0.2, p<0.05), height-for-age percentile (r=-0.3, p<0.05), and serum zinc level (r=-0.3, p=0.002). The pattern of nutrition correlated only with the weight of the infant (r=0.2, p<0.05) and not with either height or serum zinc levels (p>0.05).
Conclusions: Exclusive breastfeeding beyond 6 months of age has negative effects on serum zinc levels and can be associated with low weight gain, which will be especially important in developing countries.
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http://dx.doi.org/10.1089/bfm.2012.0014 | DOI Listing |
Discov Oncol
January 2025
Department of Otolaryngology-Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
The zinc finger protein 32 (ZNF32) has been associated with high expression in various cancers, underscoring its significant function in both cancer biology and immune response. To further elucidate the biological role of ZNF32 and identify potential immunotherapy targets in cancer, we conducted an in-depth analysis of ZNF32. We comprehensively investigated the expression of ZNF32 across tumors using diverse databases, including TCGA, CCLE, TIMER2.
View Article and Find Full Text PDFCell Signal
January 2025
Clinic School of Medicine and Affiliated Hospital, North China University of Science and Technology, Tangshan, China. Electronic address:
Purpose: This study aims to investigate whether zinc ion (Zn) alleviates myocardial ischemia-reperfusion injury (MIRI) through the MAM-associated signaling pathway and to explore its impact on ERS and calcium overload.
Methods: H9C2 cells were cultured in a DMEM supplemented with 10 % fetal bovine serum and 1 % antibiotic solution. A MIRI model was established through simulated ischemia and reoxygenation with Zn treatment in a complete medium.
IUBMB Life
January 2025
Senior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Hepatocellular carcinoma (HCC) ranks among the most prevalent types of cancer globally. Zinc finger protein 169 (ZNF169) holds significant importance as a transcription factor, yet its precise function in HCC remains to be elucidated. This study aims to examine the clinical importance, biological functions, and molecular pathways associated with ZNF169 in the development of HCC.
View Article and Find Full Text PDFBackground: Childhood obesity and the rate of its spread is a serious threat to the reproductive health of the nation, especially among boys, being a background for delaying sexual development and further disrupting fertility.
Aim: To study the peculiarities of the ratio of the level of leptin and a number of toxic and essential chemical trace elements in biological environments in adolescent boys aged 13-14 years with obesity and delayed sexual development.
Materials And Methods: Three groups of adolescents aged 13-14 years were studied and formed: the main ones - with constitutional exogenous obesity of 1-2 degrees (1-20 boys without secondary signs of puberty; 2 - 24 boys with 2-4 stages of puberty according to Tanner) and comparisons (3 - 15 boys with normal body weight and without deviations in puberty).
An optimal amount of labile zinc (Zn ) is essential for proliferation of human cells, where Zn levels that are too high or too low cause cell cycle exit. Tumors of the breast have been characterized by high levels of total Zn . Given the role of Zn in proliferation of human cells and elevation of zinc in breast cancer tumors, we examined the concentration of total and labile Zn across a panel of 5 breast cancer cell lines, compared to the normal MCF10A cell line.
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